Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Vassar | 42 | 88 | Yale | Final | W | 46 |
| 2 | 2021-11-12 | Massachusetts (182) | 71 | 91 | Yale (81) | Final | W | 20 |
| 3 | 2021-11-14 | Yale (81) | 44 | 80 | Seton Hall (53) | Final | L | -36 |
| 4 | 2021-11-16 | Yale (132) | 82 | 54 | Siena (347) | Final | W | 28 |
| 5 | 2021-11-19 | Yale (81) | 53 | 61 | Vermont (225) | Final | L | -8 |
| 6 | 2021-11-23 | Southern Utah (321) | 88 | 85 | Yale (146) | Final | L | -3 |
| 7 | 2021-11-24 | Milwaukee (261) | 56 | 69 | Yale (81) | Final | W | 13 |
| 8 | 2021-11-28 | Stony Brook (237) | 85 | 81 | Yale (213) | Final | L | -4 |
| 9 | 2021-12-01 | Lehigh (276) | 72 | 82 | Yale (81) | Final | W | 10 |
| 10 | 2021-12-04 | Yale (81) | 64 | 86 | Auburn (37) | Final | L | -22 |
| 11 | 2021-12-07 | Albany (330) | 52 | 71 | Yale (81) | Final | W | 19 |
| 12 | 2021-12-12 | Yale (81) | 77 | 91 | Iona (220) | Final | L | -14 |
| 13 | 2021-12-14 | Monmouth (176) | 69 | 60 | Yale (81) | Final | L | -9 |
| 14 | 2021-12-23 | Howard (211) | 0 | 0 | Yale (81) | Cancelled | - | - |
| 15 | 2021-12-28 | Yale (81) | 60 | 87 | Saint Mary's (33) | Final | L | -27 |
| 16 | 2022-01-02 | Columbia (193) | 0 | 0 | Yale (81) | Postponed | - | - |
| 17 | 2022-01-07 | Yale (81) | 0 | 0 | Dartmouth (256) | Postponed | - | - |
| 18 | 2022-01-15 | Cornell (187) | 69 | 96 | Yale (81) | Final | W | 27 |
| 19 | 2022-01-17 | Yale (159) | 66 | 63 | Brown (205) | Final | W | 3 |
| 20 | 2022-01-22 | Yale (81) | 68 | 76 | Penn (131) | Final | L | -8 |
| 21 | 2022-01-25 | Columbia (343) | 72 | 83 | Yale (166) | Final | W | 11 |
| 22 | 2022-01-29 | Yale (81) | 80 | 74 | Princeton (271) | Final | W | 6 |
| 23 | 2022-02-04 | Dartmouth (277) | 69 | 72 | Yale (150) | Final | W | 3 |
| 24 | 2022-02-05 | Harvard (181) | 55 | 58 | Yale (81) | Final | W | 3 |
| 25 | 2022-02-09 | Yale (81) | 62 | 59 | Harvard (181) | Final | W | 3 |
| 26 | 2022-02-12 | Yale (81) | 84 | 59 | Columbia (193) | Final | W | 25 |
| 27 | 2022-02-18 | Penn (192) | 72 | 81 | Yale (139) | Final | W | 9 |
| 28 | 2022-02-19 | Princeton (109) | 81 | 75 | Yale (139) | Final | L | -6 |
| 29 | 2022-02-22 | Yale (134) | 66 | 61 | Dartmouth (278) | Final | W | 5 |
| 30 | 2022-02-26 | Yale (134) | 65 | 71 | Cornell (198) | Final | L | -6 |
| 31 | 2022-03-05 | Brown (220) | 65 | 74 | Yale (143) | Final | W | 9 |
| 32 | 2022-03-12 | Penn (207) | 61 | 67 | Yale (141) | Final | W | 6 |
| 33 | 2022-03-13 | Yale (129) | 66 | 64 | Princeton (101) | Final | W | 2 |
| 34 | 2022-03-18 | Yale (129) | 56 | 78 | Purdue (11) | Final | L | -22 |