Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Illinois-Springfield | 0 | 0 | Bradley (181) | Cancelled | - | - |
| 2 | 2021-11-09 | Bradley (181) | 65 | 81 | South Dakota State (125) | Final | L | -16 |
| 3 | 2021-11-13 | Howard (333) | 76 | 64 | Bradley (181) | Final | L | -12 |
| 4 | 2021-11-16 | Missouri S&T | 66 | 92 | Bradley (318) | Final | W | 26 |
| 5 | 2021-11-19 | Bradley (113) | 60 | 66 | Colorado State (85) | Final | L | -6 |
| 6 | 2021-11-20 | Bradley (113) | 62 | 65 | Brown (295) | Final | L | -3 |
| 7 | 2021-11-22 | Bradley (113) | 70 | 78 | Duquesne (121) | Final | L | -8 |
| 8 | 2021-11-27 | Maine (292) | 39 | 71 | Bradley (319) | Final | W | 32 |
| 9 | 2021-12-01 | Northern Iowa (89) | 69 | 71 | Bradley (113) | Final | W | 2 |
| 10 | 2021-12-04 | SIU-Edwardsville (248) | 55 | 80 | Bradley (113) | Final | W | 25 |
| 11 | 2021-12-07 | Bradley (113) | 65 | 67 | Toledo (135) | Final | L | -2 |
| 12 | 2021-12-18 | Saint Joseph's (99) | 73 | 77 | Bradley (113) | Final | W | 4 |
| 13 | 2021-12-21 | Bradley (113) | 87 | 61 | Sam Houston State (120) | Final | W | 26 |
| 14 | 2021-12-22 | Bradley (113) | 73 | 66 | UTEP (274) | Final | W | 7 |
| 15 | 2021-12-29 | Bellarmine (266) | 0 | 0 | Bradley (113) | Cancelled | - | - |
| 16 | 2022-01-02 | Bradley (113) | 71 | 76 | Indiana State (243) | Final | L | -5 |
| 17 | 2022-01-05 | Missouri State (224) | 71 | 69 | Bradley (113) | Final | L | -2 |
| 18 | 2022-01-08 | Bradley (113) | 71 | 78 | Loyola-Chicago (263) | Final/OT | L | -7 |
| 19 | 2022-01-12 | Evansville (310) | 47 | 79 | Bradley (185) | Final | W | 32 |
| 20 | 2022-01-16 | Bradley (191) | 65 | 74 | Illinois State (212) | Final | L | -9 |
| 21 | 2022-01-19 | Bradley (113) | 83 | 71 | Drake (217) | Final | W | 12 |
| 22 | 2022-01-22 | Southern Illinois (150) | 62 | 70 | Bradley (113) | Final | W | 8 |
| 23 | 2022-01-26 | Bradley (161) | 71 | 56 | Valparaiso (193) | Final | W | 15 |
| 24 | 2022-01-30 | Indiana State (219) | 52 | 67 | Bradley (144) | Final | W | 15 |
| 25 | 2022-02-02 | Bradley (144) | 65 | 78 | Northern Iowa (138) | Final | L | -13 |
| 26 | 2022-02-05 | Bradley (113) | 76 | 41 | Evansville (302) | Final | W | 35 |
| 27 | 2022-02-09 | Loyola-Chicago (263) | 61 | 68 | Bradley (113) | Final | W | 7 |
| 28 | 2022-02-12 | Drake (217) | 59 | 68 | Bradley (113) | Final | W | 9 |
| 29 | 2022-02-15 | Bradley (124) | 57 | 65 | Southern Illinois (187) | Final | L | -8 |
| 30 | 2022-02-19 | Illinois State (248) | 64 | 72 | Bradley (124) | Final | W | 8 |
| 31 | 2022-02-23 | Bradley (129) | 67 | 83 | Missouri State (98) | Final | L | -16 |
| 32 | 2022-02-26 | Valparaiso (208) | 55 | 79 | Bradley (129) | Final | W | 24 |
| 33 | 2022-03-04 | Bradley (130) | 50 | 66 | Loyola-Chicago (53) | Final | L | -16 |