Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Southern Illinois (200) | 66 | 69 | Little Rock (231) | Final | L | -3 |
| 2 | 2021-11-12 | Austin Peay (138) | 55 | 73 | Southern Illinois (150) | Final | W | 18 |
| 3 | 2021-11-14 | Benedictine | 0 | 0 | Southern Illinois | Cancelled | - | - |
| 4 | 2021-11-19 | Southern Illinois (150) | 67 | 63 | Colorado (73) | Final | W | 4 |
| 5 | 2021-11-21 | Northeastern (136) | 59 | 47 | Southern Illinois (173) | Final | L | -12 |
| 6 | 2021-11-22 | Creighton (78) | 66 | 64 | Southern Illinois (150) | Final | L | -2 |
| 7 | 2021-11-26 | Alcorn State (348) | 59 | 62 | Southern Illinois (150) | Final | W | 3 |
| 8 | 2021-12-01 | Southern Illinois (150) | 54 | 52 | Evansville (302) | Final | W | 2 |
| 9 | 2021-12-04 | Southern Miss (201) | 41 | 66 | Southern Illinois (150) | Final | W | 25 |
| 10 | 2021-12-11 | Southern Illinois (150) | 65 | 69 | Tulsa (55) | Final | L | -4 |
| 11 | 2021-12-15 | Southeast Missouri State (226) | 55 | 80 | Southern Illinois (150) | Final | W | 25 |
| 12 | 2021-12-18 | Maryville | 55 | 75 | Southern Illinois (150) | Final | W | 20 |
| 13 | 2021-12-22 | Southern Illinois (150) | 52 | 64 | San Francisco (122) | Final | L | -12 |
| 14 | 2021-12-28 | Grambling (312) | 64 | 75 | Southern Illinois (150) | Final | W | 11 |
| 15 | 2021-12-28 | Missouri Baptist | 0 | 0 | Southern Illinois (180) | Cancelled | - | - |
| 16 | 2022-01-05 | Drake (217) | 0 | 0 | Southern Illinois (150) | Postponed | - | - |
| 17 | 2022-01-08 | Southern Illinois (150) | 63 | 60 | Valparaiso (156) | Final | W | 3 |
| 18 | 2022-01-12 | Southern Illinois (167) | 76 | 81 | Missouri State (116) | Final | L | -5 |
| 19 | 2022-01-15 | Northern Iowa (89) | 69 | 68 | Southern Illinois (150) | Final | L | -1 |
| 20 | 2022-01-17 | Drake (110) | 60 | 59 | Southern Illinois (187) | Final | L | -1 |
| 21 | 2022-01-19 | Indiana State (243) | 55 | 63 | Southern Illinois (150) | Final | W | 8 |
| 22 | 2022-01-22 | Southern Illinois (150) | 62 | 70 | Bradley (113) | Final | L | -8 |
| 23 | 2022-01-25 | Southern Illinois (192) | 47 | 59 | Loyola-Chicago (32) | Final | L | -12 |
| 24 | 2022-01-27 | Loyola-Chicago (263) | 44 | 39 | Southern Illinois (150) | Final | L | -5 |
| 25 | 2022-01-30 | Valparaiso (210) | 55 | 77 | Southern Illinois (187) | Final | W | 22 |
| 26 | 2022-02-02 | Missouri State (92) | 69 | 54 | Southern Illinois (187) | Final | L | -15 |
| 27 | 2022-02-05 | Southern Illinois (150) | 75 | 69 | Illinois State (94) | Final | W | 6 |
| 28 | 2022-02-09 | Southern Illinois (150) | 44 | 53 | Northern Iowa (89) | Final | L | -9 |
| 29 | 2022-02-12 | Evansville (302) | 62 | 69 | Southern Illinois (150) | Final | W | 7 |
| 30 | 2022-02-15 | Bradley (124) | 57 | 65 | Southern Illinois (187) | Final | W | 8 |
| 31 | 2022-02-19 | Southern Illinois (187) | 76 | 72 | Indiana State (242) | Final | W | 4 |
| 32 | 2022-02-23 | Illinois State (254) | 69 | 90 | Southern Illinois (169) | Final | W | 21 |
| 33 | 2022-02-26 | Southern Illinois (169) | 60 | 62 | Drake (104) | Final | L | -2 |
| 34 | 2022-03-04 | Southern Illinois (164) | 52 | 65 | Drake (92) | Final | L | -13 |