Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Texas State (162) | 75 | 57 | Incarnate Word (330) | Final | L | -18 |
| 2 | 2021-11-12 | Incarnate Word (280) | 60 | 87 | Baylor (58) | Final | L | -27 |
| 3 | 2021-11-16 | Concordia (TX) | 82 | 78 | Incarnate Word (350) | Final | L | -4 |
| 4 | 2021-11-20 | Texas Tech (20) | 84 | 62 | Incarnate Word (280) | Final | L | -22 |
| 5 | 2021-11-26 | Southeast Missouri State (226) | 79 | 76 | Incarnate Word (280) | Final | L | -3 |
| 6 | 2021-11-27 | Montana State (286) | 83 | 64 | Incarnate Word (358) | Final | L | -19 |
| 7 | 2021-11-28 | Portland (171) | 77 | 68 | Incarnate Word (358) | Final | L | -9 |
| 8 | 2021-12-01 | Lady of the Lake | 66 | 93 | Incarnate Word (280) | Final | W | 27 |
| 9 | 2021-12-04 | Incarnate Word (280) | 65 | 98 | Abilene Christian (245) | Final | L | -33 |
| 10 | 2021-12-11 | Grambling (312) | 62 | 72 | Incarnate Word (280) | Final | W | 10 |
| 11 | 2021-12-16 | Incarnate Word (280) | 55 | 85 | Rice (228) | Final | L | -30 |
| 12 | 2021-12-20 | Incarnate Word (280) | 59 | 79 | Purdue (8) | Final | L | -20 |
| 13 | 2021-12-28 | Incarnate Word (280) | 33 | 78 | Texas (41) | Final | L | -45 |
| 14 | 2021-12-30 | Trinity (TX) | 0 | 0 | Incarnate Word (280) | Cancelled | - | - |
| 15 | 2022-01-02 | Dallas Christian | 45 | 90 | Incarnate Word (280) | Final | W | 45 |
| 16 | 2022-01-06 | Nicholls State (250) | 87 | 56 | Incarnate Word (280) | Final | L | -31 |
| 17 | 2022-01-07 | Northwestern State (315) | 83 | 80 | Incarnate Word (280) | Final | L | -3 |
| 18 | 2022-01-08 | Houston Baptist (318) | 50 | 60 | Incarnate Word (348) | Final | W | 10 |
| 19 | 2022-01-15 | Incarnate Word (280) | 64 | 80 | Texas A&M-Corpus Christi (208) | Final | L | -16 |
| 20 | 2022-01-20 | Houston Baptist (345) | 68 | 65 | Incarnate Word (349) | Final | L | -3 |
| 21 | 2022-01-22 | McNeese State (283) | 82 | 72 | Incarnate Word (349) | Final | L | -10 |
| 22 | 2022-01-27 | Incarnate Word (280) | 70 | 79 | Northwestern State (315) | Final | L | -9 |
| 23 | 2022-01-29 | Incarnate Word (280) | 68 | 78 | Southeastern Louisiana (318) | Final | L | -10 |
| 24 | 2022-02-03 | Nicholls State (250) | 63 | 60 | Incarnate Word (280) | Final | L | -3 |
| 25 | 2022-02-05 | New Orleans (236) | 70 | 78 | Incarnate Word (280) | Final | W | 8 |
| 26 | 2022-02-10 | Incarnate Word (280) | 58 | 69 | Nicholls State (250) | Final | L | -11 |
| 27 | 2022-02-12 | Incarnate Word (280) | 57 | 84 | New Orleans (236) | Final | L | -27 |
| 28 | 2022-02-17 | Northwestern State (315) | 88 | 64 | Incarnate Word (280) | Final | L | -24 |
| 29 | 2022-02-19 | Southeastern Louisiana (264) | 84 | 92 | Incarnate Word (351) | Final | W | 8 |
| 30 | 2022-02-24 | Incarnate Word (348) | 68 | 82 | Houston Baptist (329) | Final | L | -14 |
| 31 | 2022-02-26 | Incarnate Word (348) | 69 | 67 | McNeese State (299) | Final | W | 2 |
| 32 | 2022-03-05 | Texas A&M-Corpus Christi (242) | 77 | 68 | Incarnate Word (345) | Final | L | -9 |
| 33 | 2022-03-09 | Incarnate Word (348) | 64 | 74 | Houston Baptist (323) | Final | L | -10 |