Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-30 | MSOE | 63 | 69 | Milwaukee (238) | Final | W | 6 |
| 2 | 2021-11-09 | Milwaukee (238) | 75 | 60 | North Dakota (297) | Final | W | 15 |
| 3 | 2021-11-13 | Eastern Kentucky (132) | 77 | 71 | Milwaukee (238) | Final | L | -6 |
| 4 | 2021-11-18 | Milwaukee (176) | 45 | 81 | Florida (18) | Final | L | -36 |
| 5 | 2021-11-23 | Milwaukee (218) | 68 | 82 | Bowling Green (312) | Final | L | -14 |
| 6 | 2021-11-24 | Milwaukee (261) | 56 | 69 | Yale (81) | Final | L | -13 |
| 7 | 2021-11-28 | Alcorn State (279) | 61 | 57 | Milwaukee (327) | Final | L | -4 |
| 8 | 2021-12-02 | Youngstown State (247) | 70 | 68 | Milwaukee (327) | Final | L | -2 |
| 9 | 2021-12-04 | Robert Morris (148) | 69 | 77 | Milwaukee (261) | Final | W | 8 |
| 10 | 2021-12-10 | Milwaukee (323) | 54 | 65 | Colorado (92) | Final | L | -11 |
| 11 | 2021-12-13 | Rhode Island (145) | 82 | 58 | Milwaukee (261) | Final | L | -24 |
| 12 | 2021-12-23 | St. Xavier | 52 | 74 | Milwaukee (323) | Final | W | 22 |
| 13 | 2021-12-30 | Milwaukee (261) | 75 | 80 | Wright State (124) | Final | L | -5 |
| 14 | 2022-01-01 | Milwaukee (261) | 61 | 55 | Northern Kentucky (195) | Final | W | 6 |
| 15 | 2022-01-05 | Milwaukee (261) | 63 | 49 | Green Bay (206) | Final | W | 14 |
| 16 | 2022-01-07 | Milwaukee (261) | 60 | 85 | Detroit (212) | Final | L | -25 |
| 17 | 2022-01-09 | Milwaukee (314) | 65 | 86 | Oakland (62) | Final | L | -21 |
| 18 | 2022-01-13 | Illinois-Chicago (139) | 81 | 77 | Milwaukee (261) | Final | L | -4 |
| 19 | 2022-01-15 | IUPUI (357) | 54 | 89 | Milwaukee (314) | Final | W | 35 |
| 20 | 2022-01-20 | Oakland (172) | 78 | 88 | Milwaukee (261) | Final | W | 10 |
| 21 | 2022-01-22 | Detroit (212) | 71 | 58 | Milwaukee (261) | Final | L | -13 |
| 22 | 2022-01-27 | Milwaukee (261) | 53 | 77 | Robert Morris (148) | Final | L | -24 |
| 23 | 2022-01-29 | Milwaukee (261) | 72 | 86 | Youngstown State (231) | Final | L | -14 |
| 24 | 2022-02-04 | Milwaukee (319) | 60 | 70 | Purdue Fort Wayne (254) | Final | L | -10 |
| 25 | 2022-02-06 | Milwaukee (261) | 71 | 84 | Cleveland State (308) | Final | L | -13 |
| 26 | 2022-02-09 | Northern Kentucky (195) | 75 | 39 | Milwaukee (261) | Final | L | -36 |
| 27 | 2022-02-11 | Wright State (124) | 57 | 60 | Milwaukee (261) | Final | W | 3 |
| 28 | 2022-02-13 | Green Bay (348) | 44 | 54 | Milwaukee (317) | Final | W | 10 |
| 29 | 2022-02-18 | Cleveland State (143) | 78 | 61 | Milwaukee (317) | Final | L | -17 |
| 30 | 2022-02-20 | Purdue Fort Wayne (215) | 81 | 71 | Milwaukee (321) | Final | L | -10 |
| 31 | 2022-02-24 | Milwaukee (321) | 66 | 54 | IUPUI (357) | Final | W | 12 |
| 32 | 2022-02-26 | Milwaukee (321) | 58 | 71 | Illinois-Chicago (283) | Final | L | -13 |
| 33 | 2022-03-01 | Illinois-Chicago (279) | 80 | 69 | Milwaukee (324) | Final | L | -11 |