Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Bob Jones | 79 | 117 | Wofford (112) | Final | W | 38 |
| 2 | 2021-11-12 | Wofford (221) | 68 | 76 | Clemson (36) | Final | L | -8 |
| 3 | 2021-11-15 | Erskine | 41 | 98 | Wofford (218) | Final | W | 57 |
| 4 | 2021-11-19 | Hampton (260) | 60 | 77 | Wofford (221) | Final | W | 17 |
| 5 | 2021-11-21 | Georgia Southern (97) | 52 | 70 | Wofford (87) | Final | W | 18 |
| 6 | 2021-11-23 | Wofford (87) | 74 | 85 | South Carolina (72) | Final | L | -11 |
| 7 | 2021-11-28 | Wofford (103) | 68 | 65 | Georgia (212) | Final | W | 3 |
| 8 | 2021-12-01 | Richmond (166) | 73 | 64 | Wofford (221) | Final | L | -9 |
| 9 | 2021-12-05 | Kennesaw State (217) | 62 | 88 | Wofford (103) | Final | W | 26 |
| 10 | 2021-12-08 | Wofford (128) | 78 | 70 | Gardner-Webb (192) | Final | W | 8 |
| 11 | 2021-12-12 | Wofford (221) | 59 | 60 | Coastal Carolina (188) | Final | L | -1 |
| 12 | 2021-12-18 | Wofford (221) | 76 | 49 | Presbyterian (264) | Final | W | 27 |
| 13 | 2021-12-22 | Wofford (221) | 0 | 0 | Duquesne (121) | Cancelled | - | - |
| 14 | 2021-12-29 | Virginia Military (357) | 80 | 73 | Wofford (221) | Final | L | -7 |
| 15 | 2022-01-01 | Wofford (221) | 0 | 0 | UNC-Greensboro (265) | Postponed | - | - |
| 16 | 2022-01-05 | Chattanooga (291) | 75 | 67 | Wofford (221) | Final | L | -8 |
| 17 | 2022-01-08 | Wofford (221) | 68 | 57 | East Tennessee State (140) | Final | W | 11 |
| 18 | 2022-01-10 | Wofford (129) | 54 | 58 | UNC-Greensboro (171) | Final | L | -4 |
| 19 | 2022-01-12 | Samford (159) | 64 | 87 | Wofford (129) | Final | W | 23 |
| 20 | 2022-01-15 | Wofford (221) | 84 | 64 | Western Carolina (223) | Final | W | 20 |
| 21 | 2022-01-19 | The Citadel (332) | 77 | 89 | Wofford (221) | Final | W | 12 |
| 22 | 2022-01-22 | Furman (157) | 75 | 50 | Wofford (221) | Final | L | -25 |
| 23 | 2022-01-26 | Wofford (136) | 60 | 71 | Chattanooga (61) | Final | L | -11 |
| 24 | 2022-01-29 | UNC-Greensboro (265) | 66 | 85 | Wofford (221) | Final | W | 19 |
| 25 | 2022-01-31 | Wofford (126) | 62 | 67 | Mercer (190) | Final | L | -5 |
| 26 | 2022-02-05 | East Tennessee State (140) | 60 | 62 | Wofford (221) | Final | W | 2 |
| 27 | 2022-02-09 | Wofford (221) | 60 | 65 | Samford (203) | Final/OT | L | -5 |
| 28 | 2022-02-12 | Western Carolina (223) | 57 | 69 | Wofford (221) | Final | W | 12 |
| 29 | 2022-02-16 | Wofford (137) | 65 | 58 | The Citadel (227) | Final | W | 7 |
| 30 | 2022-02-19 | Wofford (137) | 69 | 70 | Furman (100) | Final | L | -1 |
| 31 | 2022-02-23 | Wofford (132) | 83 | 72 | Virginia Military (146) | Final | W | 11 |
| 32 | 2022-02-26 | Mercer (179) | 67 | 74 | Wofford (132) | Final | W | 7 |
| 33 | 2022-03-05 | Virginia Military (166) | 66 | 68 | Wofford (125) | Final | W | 2 |
| 34 | 2022-03-06 | Wofford (125) | 56 | 79 | Chattanooga (67) | Final | L | -23 |