Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Lewis & Clark | 67 | 93 | Portland (310) | Final | W | 26 |
| 2 | 2021-11-09 | Portland (310) | 60 | 76 | Arizona State (110) | Final | L | -16 |
| 3 | 2021-11-11 | Willamette | 78 | 122 | Portland (310) | Final | W | 44 |
| 4 | 2021-11-13 | Alcorn State (329) | 58 | 62 | Portland (310) | Final | W | 4 |
| 5 | 2021-11-18 | Arkansas-Pine Bluff (336) | 74 | 86 | Portland (217) | Final | W | 12 |
| 6 | 2021-11-20 | Morgan State (337) | 63 | 74 | Portland (210) | Final | W | 11 |
| 7 | 2021-11-23 | Portland (147) | 69 | 54 | Portland State (232) | Final | W | 15 |
| 8 | 2021-11-26 | Portland (210) | 66 | 69 | Montana State (197) | Final | L | -3 |
| 9 | 2021-11-27 | Southeast Missouri State (207) | 68 | 74 | Portland (147) | Final | W | 6 |
| 10 | 2021-11-28 | Portland (171) | 77 | 68 | Incarnate Word (358) | Final | W | 9 |
| 11 | 2021-12-03 | Virginia Military (357) | 90 | 82 | Portland (210) | Final | L | -8 |
| 12 | 2021-12-13 | Cal Poly (238) | 77 | 78 | Portland (210) | Final | W | 1 |
| 13 | 2021-12-15 | Portland (210) | 71 | 96 | Oregon (102) | Final | L | -25 |
| 14 | 2021-12-17 | San Jose State (229) | 90 | 78 | Portland (210) | Final | L | -12 |
| 15 | 2021-12-19 | Portland (210) | 59 | 61 | Montana State (197) | Final | L | -2 |
| 16 | 2021-12-22 | Portland (210) | 65 | 60 | UC-Davis (170) | Final | W | 5 |
| 17 | 2022-01-01 | BYU (23) | 0 | 0 | Portland (210) | Canceled | - | - |
| 18 | 2022-01-13 | Portland (210) | 63 | 68 | San Diego (246) | Final/OT | L | -5 |
| 19 | 2022-01-15 | Portland (210) | 82 | 63 | Pepperdine (283) | Final | W | 19 |
| 20 | 2022-01-17 | Portland (226) | 58 | 70 | Loyola Marymount (164) | Final | L | -12 |
| 21 | 2022-01-22 | Portland (210) | 65 | 78 | BYU (23) | Final | L | -13 |
| 22 | 2022-01-27 | Pacific (132) | 56 | 64 | Portland (210) | Final | W | 8 |
| 23 | 2022-01-29 | Portland (210) | 72 | 104 | Gonzaga (11) | Final | L | -32 |
| 24 | 2022-02-03 | Saint Mary's (33) | 75 | 54 | Portland (210) | Final | L | -21 |
| 25 | 2022-02-05 | San Francisco (122) | 74 | 71 | Portland (210) | Final | L | -3 |
| 26 | 2022-02-08 | Portland (226) | 69 | 68 | San Francisco (32) | Final | W | 1 |
| 27 | 2022-02-12 | Loyola Marymount (184) | 76 | 86 | Portland (210) | Final | W | 10 |
| 28 | 2022-02-14 | Santa Clara (42) | 0 | 0 | Portland (210) | Canceled | - | - |
| 29 | 2022-02-15 | Bushnell | 39 | 84 | Portland (200) | Final | W | 45 |
| 30 | 2022-02-17 | San Diego (246) | 60 | 92 | Portland (210) | Final | W | 32 |
| 31 | 2022-02-19 | Pepperdine (286) | 74 | 77 | Portland (200) | Final | W | 3 |
| 32 | 2022-02-24 | Portland (180) | 75 | 69 | Pacific (294) | Final | W | 6 |
| 33 | 2022-02-26 | Portland (180) | 89 | 102 | Santa Clara (75) | Final | L | -13 |
| 34 | 2022-03-04 | San Diego (196) | 55 | 73 | Portland (182) | Final | W | 18 |
| 35 | 2022-03-06 | Portland (176) | 67 | 91 | Santa Clara (68) | Final | L | -24 |
| 36 | 2022-03-19 | New Orleans (241) | 73 | 94 | Portland (179) | Final | W | 21 |
| 37 | 2022-03-26 | Portland (179) | 66 | 77 | Southern Utah (177) | Final | L | -11 |