Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Youngstown State (258) | 59 | 75 | Penn State (58) | Final | L | -16 |
| 2 | 2021-11-13 | Youngstown State (258) | 97 | 79 | Southeast Missouri State (276) | Final | W | 18 |
| 3 | 2021-11-19 | St. Thomas (137) | 75 | 79 | Youngstown State (231) | Final | W | 4 |
| 4 | 2021-11-20 | SIU-Edwardsville (248) | 69 | 66 | Youngstown State (231) | Final | L | -3 |
| 5 | 2021-11-21 | Niagara (204) | 58 | 53 | Youngstown State (237) | Final | L | -5 |
| 6 | 2021-12-02 | Youngstown State (247) | 70 | 68 | Milwaukee (327) | Final | W | 2 |
| 7 | 2021-12-04 | Youngstown State (231) | 82 | 58 | Green Bay (206) | Final | W | 24 |
| 8 | 2021-12-08 | Central Michigan (338) | 77 | 84 | Youngstown State (219) | Final | W | 7 |
| 9 | 2021-12-11 | Canisius (328) | 43 | 71 | Youngstown State (231) | Final | W | 28 |
| 10 | 2021-12-18 | Westminster (PA) | 54 | 83 | Youngstown State (231) | Final | W | 29 |
| 11 | 2021-12-22 | Youngstown State (231) | 52 | 82 | West Virginia (50) | Final | L | -30 |
| 12 | 2021-12-29 | Defiance | 56 | 96 | Youngstown State (231) | Final | W | 40 |
| 13 | 2021-12-30 | Youngstown State (231) | 0 | 0 | Detroit (212) | Cancelled | - | - |
| 14 | 2022-01-01 | Youngstown State (231) | 72 | 87 | Oakland (172) | Final | L | -15 |
| 15 | 2022-01-05 | Youngstown State (231) | 64 | 60 | Robert Morris (148) | Final | W | 4 |
| 16 | 2022-01-07 | Purdue Fort Wayne (222) | 71 | 61 | Youngstown State (231) | Final | L | -10 |
| 17 | 2022-01-09 | Cleveland State (133) | 86 | 80 | Youngstown State (238) | Final (OT) | L | -6 |
| 18 | 2022-01-13 | Northern Kentucky (195) | 68 | 67 | Youngstown State (231) | Final | L | -1 |
| 19 | 2022-01-15 | Wright State (124) | 87 | 90 | Youngstown State (231) | Final | W | 3 |
| 20 | 2022-01-21 | Youngstown State (241) | 61 | 64 | Cleveland State (136) | Final | L | -3 |
| 21 | 2022-01-23 | Youngstown State (251) | 71 | 82 | Purdue Fort Wayne (230) | Final | L | -11 |
| 22 | 2022-01-27 | Green Bay (206) | 50 | 63 | Youngstown State (231) | Final | W | 13 |
| 23 | 2022-01-29 | Milwaukee (261) | 72 | 86 | Youngstown State (231) | Final | W | 14 |
| 24 | 2022-02-03 | Youngstown State (231) | 61 | 55 | IU-Indy (338) | Final | W | 6 |
| 25 | 2022-02-03 | Youngstown State (243) | 61 | 55 | IUPUI (358) | Final | W | 6 |
| 26 | 2022-02-05 | Youngstown State (231) | 66 | 64 | Illinois-Chicago (139) | Final | W | 2 |
| 27 | 2022-02-09 | Oakland (172) | 71 | 78 | Youngstown State (231) | Final | W | 7 |
| 28 | 2022-02-11 | Detroit (212) | 69 | 82 | Youngstown State (231) | Final | W | 13 |
| 29 | 2022-02-13 | Robert Morris (320) | 73 | 68 | Youngstown State (235) | Final | L | -5 |
| 30 | 2022-02-17 | Illinois-Chicago (139) | 79 | 88 | Youngstown State (231) | Final | W | 9 |
| 31 | 2022-02-19 | IUPUI (358) | 61 | 74 | Youngstown State (235) | Final | W | 13 |
| 32 | 2022-02-24 | Youngstown State (227) | 71 | 84 | Wright State (224) | Final | L | -13 |
| 33 | 2022-02-26 | Youngstown State (227) | 61 | 75 | Northern Kentucky (223) | Final | L | -14 |
| 34 | 2022-03-01 | Robert Morris (342) | 77 | 73 | Youngstown State (239) | Final | L | -4 |
| 35 | 2022-03-16 | Morgan State (337) | 65 | 70 | Youngstown State (231) | Final | W | 5 |
| 36 | 2022-03-23 | Youngstown State (249) | 71 | 80 | Fresno State (91) | Final | L | -9 |