Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Earlham | 54 | 103 | Purdue Fort Wayne (286) | Final | W | 49 |
| 2 | 2021-11-16 | Austin Peay (307) | 60 | 65 | Purdue Fort Wayne (145) | Final | W | 5 |
| 3 | 2021-11-19 | Purdue Fort Wayne (222) | 49 | 78 | Minnesota (87) | Final | L | -29 |
| 4 | 2021-11-26 | Southeastern Louisiana (318) | 66 | 74 | Purdue Fort Wayne (222) | Final | W | 8 |
| 5 | 2021-11-27 | Purdue Fort Wayne (151) | 85 | 93 | Western Michigan (356) | Final (OT) | L | -8 |
| 6 | 2021-11-28 | Purdue Fort Wayne (235) | 78 | 85 | Florida Gulf Coast (98) | Final | L | -7 |
| 7 | 2021-12-02 | Wright State (344) | 86 | 73 | Purdue Fort Wayne (235) | Final | L | -13 |
| 8 | 2021-12-04 | Northern Kentucky (195) | 57 | 71 | Purdue Fort Wayne (222) | Final | W | 14 |
| 9 | 2021-12-08 | Purdue Fort Wayne (253) | 59 | 80 | SIU-Edwardsville (306) | Final | L | -21 |
| 10 | 2021-12-11 | Southeast Missouri State (226) | 65 | 78 | Purdue Fort Wayne (222) | Final | W | 13 |
| 11 | 2021-12-21 | Purdue Fort Wayne (222) | 0 | 0 | Michigan (1) | Cancelled | - | - |
| 12 | 2021-12-30 | Purdue Fort Wayne (222) | 81 | 90 | Cleveland State (308) | Final | L | -9 |
| 13 | 2021-12-30 | Purdue Fort Wayne (266) | 0 | 0 | Illinois-Chicago (260) | Cancelled | - | - |
| 14 | 2022-01-01 | Purdue Fort Wayne (222) | 0 | 0 | IU-Indy (338) | Canceled | - | - |
| 15 | 2022-01-05 | Purdue Fort Wayne (222) | 58 | 65 | Cleveland State (308) | Final | L | -7 |
| 16 | 2022-01-07 | Purdue Fort Wayne (222) | 71 | 61 | Youngstown State (231) | Final | W | 10 |
| 17 | 2022-01-09 | Purdue Fort Wayne (266) | 76 | 70 | Robert Morris (346) | Final | W | 6 |
| 18 | 2022-01-13 | Detroit (212) | 60 | 62 | Purdue Fort Wayne (222) | Final | W | 2 |
| 19 | 2022-01-15 | Oakland (172) | 76 | 68 | Purdue Fort Wayne (222) | Final | L | -8 |
| 20 | 2022-01-17 | Michigan-Dearborn | 59 | 102 | Purdue Fort Wayne (260) | Final | W | 43 |
| 21 | 2022-01-21 | Robert Morris (334) | 62 | 86 | Purdue Fort Wayne (260) | Final | W | 24 |
| 22 | 2022-01-23 | Youngstown State (251) | 71 | 82 | Purdue Fort Wayne (230) | Final | W | 11 |
| 23 | 2022-01-28 | Purdue Fort Wayne (230) | 49 | 59 | Northern Kentucky (286) | Final | L | -10 |
| 24 | 2022-01-30 | Purdue Fort Wayne (254) | 63 | 75 | Wright State (232) | Final | L | -12 |
| 25 | 2022-02-04 | Milwaukee (319) | 60 | 70 | Purdue Fort Wayne (254) | Final | W | 10 |
| 26 | 2022-02-06 | Green Bay (206) | 55 | 71 | Purdue Fort Wayne (222) | Final | W | 16 |
| 27 | 2022-02-10 | IU-Indy (338) | 57 | 72 | Purdue Fort Wayne (222) | Final | W | 15 |
| 28 | 2022-02-10 | IUPUI (358) | 57 | 72 | Purdue Fort Wayne (238) | Final | W | 15 |
| 29 | 2022-02-12 | Illinois-Chicago (139) | 66 | 73 | Purdue Fort Wayne (222) | Final | W | 7 |
| 30 | 2022-02-14 | Cleveland State (308) | 98 | 102 | Purdue Fort Wayne (222) | Final/3OT | W | 4 |
| 31 | 2022-02-18 | Purdue Fort Wayne (231) | 74 | 55 | Green Bay (348) | Final | W | 19 |
| 32 | 2022-02-20 | Purdue Fort Wayne (215) | 81 | 71 | Milwaukee (321) | Final | W | 10 |
| 33 | 2022-02-24 | Purdue Fort Wayne (215) | 81 | 70 | Oakland (143) | Final | W | 11 |
| 34 | 2022-02-26 | Purdue Fort Wayne (215) | 81 | 78 | Detroit (244) | Final | W | 3 |
| 35 | 2022-03-03 | Illinois-Chicago (279) | 72 | 78 | Purdue Fort Wayne (199) | Final | W | 6 |
| 36 | 2022-03-07 | Northern Kentucky (201) | 57 | 43 | Purdue Fort Wayne (199) | Final | L | -14 |
| 37 | 2022-03-19 | Drake (86) | 87 | 65 | Purdue Fort Wayne (203) | Final | L | -22 |