Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Detroit (192) | 47 | 85 | Wyoming (145) | Final | L | -38 |
| 2 | 2021-11-13 | Detroit (192) | 73 | 81 | Toledo (76) | Final | L | -8 |
| 3 | 2021-11-17 | Detroit (212) | 64 | 77 | Mississippi State (100) | Final | L | -13 |
| 4 | 2021-11-20 | Detroit (212) | 67 | 73 | Louisville (21) | Final | L | -6 |
| 5 | 2021-11-27 | Detroit (316) | 84 | 98 | Hofstra (194) | Final | L | -14 |
| 6 | 2021-11-30 | Detroit (314) | 56 | 66 | Northeastern (196) | Final | L | -10 |
| 7 | 2021-12-02 | Detroit (314) | 69 | 45 | IUPUI (355) | Final | W | 24 |
| 8 | 2021-12-05 | Detroit (314) | 64 | 56 | Illinois-Chicago (275) | Final | W | 8 |
| 9 | 2021-12-09 | Detroit (270) | 52 | 69 | Kent State (121) | Final | L | -17 |
| 10 | 2021-12-11 | Western Michigan (304) | 64 | 83 | Detroit (212) | Final | W | 19 |
| 11 | 2021-12-19 | Central Michigan (311) | 75 | 89 | Detroit (212) | Final | W | 14 |
| 12 | 2021-12-30 | Youngstown State (231) | 0 | 0 | Detroit (212) | Cancelled | - | - |
| 13 | 2022-01-01 | Robert Morris (148) | 0 | 0 | Detroit (212) | Canceled | - | - |
| 14 | 2022-01-05 | Oakland (172) | 0 | 0 | Detroit (212) | Canceled | - | - |
| 15 | 2022-01-07 | Milwaukee (261) | 60 | 85 | Detroit (212) | Final | W | 25 |
| 16 | 2022-01-13 | Detroit (212) | 60 | 62 | Purdue Fort Wayne (222) | Final | L | -2 |
| 17 | 2022-01-15 | Detroit (212) | 70 | 72 | Cleveland State (308) | Final | L | -2 |
| 18 | 2022-01-20 | Detroit (212) | 63 | 70 | Green Bay (206) | Final | L | -7 |
| 19 | 2022-01-22 | Detroit (212) | 71 | 58 | Milwaukee (261) | Final | W | 13 |
| 20 | 2022-01-27 | Illinois-Chicago (139) | 67 | 80 | Detroit (212) | Final | W | 13 |
| 21 | 2022-01-29 | IU-Indy (338) | 0 | 0 | Detroit (212) | Canceled | - | - |
| 22 | 2022-01-31 | Michigan-Dearborn | 51 | 96 | Detroit (267) | Final | W | 45 |
| 23 | 2022-02-03 | Detroit (212) | 0 | 0 | Wright State (124) | Postponed | - | - |
| 24 | 2022-02-04 | Detroit (267) | 59 | 90 | Wright State (232) | Final | L | -31 |
| 25 | 2022-02-05 | Detroit (212) | 74 | 68 | Northern Kentucky (195) | Final | W | 6 |
| 26 | 2022-02-07 | Rochester (MI) | 0 | 0 | Detroit (212) | Canceled | - | - |
| 27 | 2022-02-09 | Detroit (212) | 79 | 62 | Robert Morris (148) | Final | W | 17 |
| 28 | 2022-02-11 | Detroit (212) | 69 | 82 | Youngstown State (231) | Final | L | -13 |
| 29 | 2022-02-13 | Detroit (267) | 59 | 75 | Oakland (117) | Final | L | -16 |
| 30 | 2022-02-18 | Northern Kentucky (215) | 52 | 60 | Detroit (267) | Final | W | 8 |
| 31 | 2022-02-20 | Wright State (224) | 75 | 80 | Detroit (244) | Final | W | 5 |
| 32 | 2022-02-24 | Cleveland State (161) | 67 | 74 | Detroit (244) | Final | W | 7 |
| 33 | 2022-02-26 | Purdue Fort Wayne (215) | 81 | 78 | Detroit (244) | Final | L | -3 |
| 34 | 2022-03-01 | Green Bay (349) | 62 | 79 | Detroit (237) | Final | W | 17 |
| 35 | 2022-03-03 | Detroit (237) | 59 | 77 | Northern Kentucky (206) | Final | L | -18 |
| 36 | 2022-03-16 | Detroit (212) | 79 | 95 | Florida Gulf Coast (241) | Final | L | -16 |