Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | St. Thomas | 72 | 77 | Chicago State (346) | Final | L | -5 |
| 2 | 2021-11-13 | St. Thomas | 91 | 73 | St. Francis (NY) (229) | Final | W | 18 |
| 3 | 2021-11-15 | St. Thomas (163) | 78 | 84 | Fordham (183) | Final | L | -6 |
| 4 | 2021-11-19 | St. Thomas (137) | 75 | 79 | Youngstown State (231) | Final | L | -4 |
| 5 | 2021-11-20 | Niagara (342) | 67 | 76 | St. Thomas (137) | Final | W | 9 |
| 6 | 2021-11-20 | St. Thomas (163) | 76 | 67 | Niagara (274) | Final | W | 9 |
| 7 | 2021-11-21 | St. Thomas (217) | 86 | 73 | SIU-Edwardsville (289) | Final | W | 13 |
| 8 | 2021-11-27 | St. Thomas (217) | 64 | 81 | Seattle (107) | Final | L | -17 |
| 9 | 2021-12-02 | Crown College | 53 | 73 | St. Thomas (256) | Final | W | 20 |
| 10 | 2021-12-05 | St. Thomas (256) | 64 | 74 | Drake (135) | Final | L | -10 |
| 11 | 2021-12-11 | Montana State (197) | 72 | 65 | St. Thomas (137) | Final | L | -7 |
| 12 | 2021-12-14 | Northland | 50 | 109 | St. Thomas (137) | Final | W | 59 |
| 13 | 2021-12-20 | St. Thomas (137) | 80 | 73 | Nebraska-Omaha (272) | Final | W | 7 |
| 14 | 2021-12-22 | St. Thomas (137) | 74 | 75 | Denver (253) | Final | L | -1 |
| 15 | 2021-12-29 | North Central | 45 | 97 | St. Thomas (137) | Final | W | 52 |
| 16 | 2022-01-01 | Western Illinois (362) | 66 | 89 | St. Thomas (137) | Final | W | 23 |
| 17 | 2022-01-06 | Oral Roberts (327) | 81 | 66 | St. Thomas (137) | Final | L | -15 |
| 18 | 2022-01-08 | UMKC (364) | 0 | 0 | St. Thomas (137) | Postponed | - | - |
| 19 | 2022-01-13 | St. Thomas (137) | 0 | 0 | North Dakota State (117) | Postponed | - | - |
| 20 | 2022-01-15 | St. Thomas (137) | 0 | 0 | North Dakota (251) | Postponed | - | - |
| 21 | 2022-01-20 | South Dakota State (268) | 92 | 77 | St. Thomas (137) | Final | L | -15 |
| 22 | 2022-01-22 | South Dakota (275) | 90 | 79 | St. Thomas (137) | Final | L | -11 |
| 23 | 2022-01-25 | St. Thomas (270) | 56 | 77 | North Dakota State (187) | Final | L | -21 |
| 24 | 2022-01-29 | St. Thomas (137) | 52 | 81 | Western Illinois (362) | Final | L | -29 |
| 25 | 2022-02-03 | St. Thomas (137) | 72 | 81 | UMKC (364) | Final | L | -9 |
| 26 | 2022-02-05 | St. Thomas (137) | 66 | 88 | Oral Roberts (327) | Final | L | -22 |
| 27 | 2022-02-08 | UMKC (199) | 76 | 67 | St. Thomas (294) | Final | L | -9 |
| 28 | 2022-02-10 | North Dakota (251) | 78 | 70 | St. Thomas (137) | Final | L | -8 |
| 29 | 2022-02-12 | North Dakota State (117) | 75 | 64 | St. Thomas (137) | Final | L | -11 |
| 30 | 2022-02-17 | St. Thomas (137) | 60 | 81 | South Dakota (275) | Final | L | -21 |
| 31 | 2022-02-19 | St. Thomas (310) | 60 | 79 | South Dakota State (57) | Final | L | -19 |
| 32 | 2022-02-22 | St. Thomas (313) | 84 | 74 | North Dakota (344) | Final | W | 10 |
| 33 | 2022-02-24 | Denver (320) | 91 | 80 | St. Thomas (313) | Final | L | -11 |
| 34 | 2022-02-26 | Nebraska-Omaha (343) | 74 | 95 | St. Thomas (313) | Final | W | 21 |