Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Quincy | 62 | 61 | SIU-Edwardsville (314) | Final | L | -1 |
| 2 | 2021-11-09 | SIU-Edwardsville (314) | 77 | 88 | Marquette (85) | Final | L | -11 |
| 3 | 2021-11-12 | SIU-Edwardsville (248) | 56 | 67 | Chicago State (351) | Final | L | -11 |
| 4 | 2021-11-15 | Knox | 37 | 75 | SIU-Edwardsville (283) | Final | W | 38 |
| 5 | 2021-11-19 | Niagara (342) | 70 | 60 | SIU-Edwardsville (248) | Final | L | -10 |
| 6 | 2021-11-20 | SIU-Edwardsville (248) | 69 | 66 | Youngstown State (231) | Final | W | 3 |
| 7 | 2021-11-21 | St. Thomas (217) | 86 | 73 | SIU-Edwardsville (289) | Final | L | -13 |
| 8 | 2021-11-27 | SIU-Edwardsville (289) | 65 | 70 | Creighton (78) | Final | L | -5 |
| 9 | 2021-11-30 | SIU-Edwardsville (304) | 75 | 65 | Nebraska-Omaha (345) | Final | W | 10 |
| 10 | 2021-12-04 | SIU-Edwardsville (248) | 55 | 80 | Bradley (113) | Final | L | -25 |
| 11 | 2021-12-08 | Purdue Fort Wayne (253) | 59 | 80 | SIU-Edwardsville (306) | Final | W | 21 |
| 12 | 2021-12-12 | UMKC (364) | 56 | 60 | SIU-Edwardsville (248) | Final | W | 4 |
| 13 | 2021-12-19 | William Woods | 29 | 84 | SIU-Edwardsville (248) | Final | W | 55 |
| 14 | 2021-12-21 | SIU-Edwardsville (248) | 69 | 84 | South Alabama (177) | Final | L | -15 |
| 15 | 2021-12-30 | Belmont (68) | 0 | 0 | SIU-Edwardsville (248) | Postponed | - | - |
| 16 | 2022-01-01 | SIU-Edwardsville (248) | 0 | 0 | Tennessee-Martin (205) | Postponed | - | - |
| 17 | 2022-01-08 | Murray State (116) | 74 | 69 | SIU-Edwardsville (248) | Final | L | -5 |
| 18 | 2022-01-13 | SIU-Edwardsville (248) | 66 | 53 | Eastern Illinois (314) | Final | W | 13 |
| 19 | 2022-01-15 | Southeast Missouri State (226) | 0 | 0 | SIU-Edwardsville (248) | Postponed | - | - |
| 20 | 2022-01-17 | Belmont (47) | 80 | 64 | SIU-Edwardsville (259) | Final | L | -16 |
| 21 | 2022-01-20 | SIU-Edwardsville (248) | 76 | 94 | Tennessee Tech (310) | Final | L | -18 |
| 22 | 2022-01-22 | SIU-Edwardsville (248) | 74 | 77 | Morehead State (233) | Final | L | -3 |
| 23 | 2022-01-24 | SIU-Edwardsville (248) | 70 | 76 | Tennessee-Martin (205) | Final | L | -6 |
| 24 | 2022-01-27 | Tennessee State (165) | 75 | 70 | SIU-Edwardsville (248) | Final | L | -5 |
| 25 | 2022-01-29 | SIU-Edwardsville (248) | 77 | 85 | Southeast Missouri State (226) | Final | L | -8 |
| 26 | 2022-01-31 | SIU-Edwardsville (301) | 63 | 68 | Austin Peay (302) | Final (2OT) | L | -5 |
| 27 | 2022-02-03 | Eastern Illinois (314) | 0 | 0 | SIU-Edwardsville (248) | Postponed | - | - |
| 28 | 2022-02-05 | SIU-Edwardsville (248) | 59 | 79 | Murray State (116) | Final | L | -20 |
| 29 | 2022-02-07 | Southeast Missouri State (226) | 76 | 47 | SIU-Edwardsville (248) | Final | L | -29 |
| 30 | 2022-02-10 | Tennessee-Martin (205) | 63 | 71 | SIU-Edwardsville (248) | Final | W | 8 |
| 31 | 2022-02-12 | Tennessee Tech (310) | 60 | 61 | SIU-Edwardsville (248) | Final | W | 1 |
| 32 | 2022-02-17 | SIU-Edwardsville (248) | 65 | 81 | Tennessee State (165) | Final | L | -16 |
| 33 | 2022-02-19 | SIU-Edwardsville (305) | 62 | 73 | Belmont (49) | Final | L | -11 |
| 34 | 2022-02-21 | Eastern Illinois (353) | 52 | 66 | SIU-Edwardsville (310) | Final | W | 14 |
| 35 | 2022-02-24 | Austin Peay (275) | 68 | 64 | SIU-Edwardsville (310) | Final | L | -4 |
| 36 | 2022-02-26 | Morehead State (131) | 70 | 77 | SIU-Edwardsville (310) | Final | W | 7 |
| 37 | 2022-03-02 | SIU-Edwardsville (302) | 62 | 77 | Tennessee State (293) | Final | L | -15 |