Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Southeast Missouri State (276) | 99 | 94 | Missouri State (94) | Final | W | 5 |
| 2 | 2021-11-13 | Youngstown State (258) | 97 | 79 | Southeast Missouri State (276) | Final | L | -18 |
| 3 | 2021-11-19 | Arkansas State (147) | 72 | 60 | Southeast Missouri State (226) | Final | L | -12 |
| 4 | 2021-11-22 | Missouri Baptist | 63 | 71 | Southeast Missouri State (226) | Final | W | 8 |
| 5 | 2021-11-26 | Southeast Missouri State (226) | 79 | 76 | Incarnate Word (280) | Final | W | 3 |
| 6 | 2021-11-27 | Southeast Missouri State (207) | 68 | 74 | Portland (147) | Final | L | -6 |
| 7 | 2021-11-28 | Southeast Missouri State (278) | 68 | 75 | Montana State (191) | Final | L | -7 |
| 8 | 2021-12-04 | Webster | 64 | 76 | Southeast Missouri State (226) | Final | W | 12 |
| 9 | 2021-12-08 | Evansville (280) | 73 | 75 | Southeast Missouri State (288) | Final | W | 2 |
| 10 | 2021-12-11 | Southeast Missouri State (226) | 65 | 78 | Purdue Fort Wayne (222) | Final | L | -13 |
| 11 | 2021-12-15 | Southeast Missouri State (226) | 55 | 80 | Southern Illinois (150) | Final | L | -25 |
| 12 | 2021-12-18 | Southeast Missouri State (226) | 77 | 83 | Pepperdine (283) | Final | L | -6 |
| 13 | 2021-12-21 | Southeast Missouri State (226) | 68 | 84 | California Baptist (97) | Final | L | -16 |
| 14 | 2021-12-30 | Southeast Missouri State (226) | 81 | 106 | Murray State (116) | Final | L | -25 |
| 15 | 2022-01-01 | Austin Peay (138) | 79 | 98 | Southeast Missouri State (226) | Final | W | 19 |
| 16 | 2022-01-06 | Southeast Missouri State (226) | 62 | 102 | Belmont (68) | Final | L | -40 |
| 17 | 2022-01-08 | Southeast Missouri State (226) | 84 | 95 | Tennessee State (165) | Final | L | -11 |
| 18 | 2022-01-15 | Southeast Missouri State (226) | 0 | 0 | SIU-Edwardsville (248) | Postponed | - | - |
| 19 | 2022-01-20 | Tennessee State (165) | 63 | 85 | Southeast Missouri State (226) | Final | W | 22 |
| 20 | 2022-01-22 | Southeast Missouri State (226) | 87 | 58 | Eastern Illinois (314) | Final | W | 29 |
| 21 | 2022-01-27 | Morehead State (233) | 74 | 73 | Southeast Missouri State (226) | Final/OT | L | -1 |
| 22 | 2022-01-29 | SIU-Edwardsville (248) | 77 | 85 | Southeast Missouri State (226) | Final | W | 8 |
| 23 | 2022-02-03 | Southeast Missouri State (226) | 63 | 84 | Tennessee-Martin (205) | Final | L | -21 |
| 24 | 2022-02-05 | Eastern Illinois (314) | 56 | 63 | Southeast Missouri State (226) | Final | W | 7 |
| 25 | 2022-02-07 | Southeast Missouri State (226) | 76 | 47 | SIU-Edwardsville (248) | Final | W | 29 |
| 26 | 2022-02-10 | Southeast Missouri State (226) | 66 | 74 | Austin Peay (138) | Final | L | -8 |
| 27 | 2022-02-12 | Belmont (68) | 81 | 72 | Southeast Missouri State (226) | Final | L | -9 |
| 28 | 2022-02-17 | Southeast Missouri State (226) | 94 | 98 | Tennessee Tech (310) | Final | L | -4 |
| 29 | 2022-02-19 | Southeast Missouri State (302) | 92 | 84 | Morehead State (116) | Final | W | 8 |
| 30 | 2022-02-24 | Tennessee-Martin (319) | 69 | 76 | Southeast Missouri State (298) | Final | W | 7 |
| 31 | 2022-02-26 | Murray State (23) | 70 | 68 | Southeast Missouri State (298) | Final | L | -2 |
| 32 | 2022-03-03 | Tennessee State (293) | 55 | 79 | Southeast Missouri State (288) | Final | W | 24 |
| 33 | 2022-03-04 | Southeast Missouri State (288) | 74 | 88 | Murray State (22) | Final | L | -14 |