Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-30 | Ashland | 87 | 78 | Valparaiso (245) | Final | L | -9 |
| 2 | 2021-11-04 | Flagler | 70 | 67 | Valparaiso (245) | Final | L | -3 |
| 3 | 2021-11-09 | Toledo (76) | 69 | 61 | Valparaiso (245) | Final | L | -8 |
| 4 | 2021-11-13 | Illinois-Chicago (284) | 74 | 70 | Valparaiso (245) | Final | L | -4 |
| 5 | 2021-11-17 | Valparaiso (156) | 60 | 74 | Stanford (60) | Final | L | -14 |
| 6 | 2021-11-22 | Jacksonville State (227) | 70 | 78 | Valparaiso (156) | Final | W | 8 |
| 7 | 2021-11-23 | Coastal Carolina (294) | 64 | 61 | Valparaiso (340) | Final | L | -3 |
| 8 | 2021-11-24 | Valparaiso (156) | 68 | 64 | Tulane (167) | Final | W | 4 |
| 9 | 2021-11-27 | Trinity (IL) | 69 | 106 | Valparaiso (340) | Final | W | 37 |
| 10 | 2021-12-02 | Valparaiso (259) | 66 | 73 | Drake (135) | Final | L | -7 |
| 11 | 2021-12-05 | Valparaiso (259) | 71 | 60 | Western Michigan (309) | Final | W | 11 |
| 12 | 2021-12-07 | East-West University | 58 | 101 | Valparaiso (156) | Final | W | 43 |
| 13 | 2021-12-11 | Charlotte (173) | 68 | 67 | Valparaiso (156) | Final | L | -1 |
| 14 | 2021-12-20 | Eastern Michigan (277) | 55 | 67 | Valparaiso (156) | Final | W | 12 |
| 15 | 2021-12-22 | William & Mary (141) | 66 | 88 | Valparaiso (156) | Final | W | 22 |
| 16 | 2021-12-28 | Prairie View A&M (285) | 0 | 0 | Valparaiso (156) | Cancelled | - | - |
| 17 | 2022-01-02 | Illinois State (94) | 76 | 81 | Valparaiso (156) | Final/OT | W | 5 |
| 18 | 2022-01-05 | Valparaiso (156) | 65 | 92 | Northern Iowa (89) | Final | L | -27 |
| 19 | 2022-01-08 | Southern Illinois (150) | 63 | 60 | Valparaiso (156) | Final | L | -3 |
| 20 | 2022-01-11 | Valparaiso (156) | 74 | 81 | Loyola-Chicago (263) | Final/2OT | L | -7 |
| 21 | 2022-01-15 | Missouri State (224) | 74 | 57 | Valparaiso (156) | Final | L | -17 |
| 22 | 2022-01-19 | Northern Iowa (89) | 80 | 83 | Valparaiso (156) | Final/OT | W | 3 |
| 23 | 2022-01-22 | Valparaiso (156) | 75 | 73 | Indiana State (243) | Final | W | 2 |
| 24 | 2022-01-26 | Bradley (161) | 71 | 56 | Valparaiso (193) | Final | L | -15 |
| 25 | 2022-01-30 | Valparaiso (210) | 55 | 77 | Southern Illinois (187) | Final | L | -22 |
| 26 | 2022-02-05 | Indiana State (243) | 72 | 79 | Valparaiso (156) | Final/2OT | W | 7 |
| 27 | 2022-02-09 | Valparaiso (156) | 75 | 78 | Illinois State (94) | Final/OT | L | -3 |
| 28 | 2022-02-12 | Valparaiso (156) | 66 | 84 | Missouri State (224) | Final | L | -18 |
| 29 | 2022-02-16 | Loyola-Chicago (40) | 71 | 69 | Valparaiso (212) | Final | L | -2 |
| 30 | 2022-02-19 | Valparaiso (212) | 72 | 56 | Evansville (312) | Final | W | 16 |
| 31 | 2022-02-21 | Evansville (318) | 69 | 74 | Valparaiso (208) | Final | W | 5 |
| 32 | 2022-02-23 | Drake (104) | 71 | 65 | Valparaiso (208) | Final | L | -6 |
| 33 | 2022-02-26 | Valparaiso (208) | 55 | 79 | Bradley (129) | Final | L | -24 |
| 34 | 2022-03-03 | Evansville (322) | 59 | 81 | Valparaiso (212) | Final | W | 22 |
| 35 | 2022-03-04 | Valparaiso (212) | 58 | 67 | Missouri State (91) | Final | L | -9 |