Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Fairfield (266) | 73 | 80 | Providence (79) | Final | L | -7 |
| 2 | 2021-11-14 | Fairfield (204) | 64 | 72 | Boston College (151) | Final | L | -8 |
| 3 | 2021-11-16 | Medgar Evers | 55 | 110 | Fairfield (253) | Final | W | 55 |
| 4 | 2021-11-20 | Fairfield (204) | 71 | 61 | Sacred Heart (270) | Final | W | 10 |
| 5 | 2021-11-24 | Stony Brook (213) | 78 | 83 | Fairfield (204) | Final/OT | W | 5 |
| 6 | 2021-11-28 | Loyola-Maryland (286) | 75 | 70 | Fairfield (205) | Final | L | -5 |
| 7 | 2021-12-03 | Fairfield (204) | 74 | 68 | Canisius (328) | Final | W | 6 |
| 8 | 2021-12-05 | Fairfield (205) | 81 | 71 | Niagara (207) | Final | W | 10 |
| 9 | 2021-12-08 | Holy Cross (344) | 59 | 74 | Fairfield (145) | Final | W | 15 |
| 10 | 2021-12-12 | Fairfield (204) | 70 | 47 | William & Mary (141) | Final | W | 23 |
| 11 | 2021-12-15 | Fairfield (204) | 72 | 54 | Fairleigh Dickinson (343) | Final | W | 18 |
| 12 | 2021-12-19 | Fairfield (204) | 73 | 77 | Massachusetts (182) | Final/OT | L | -4 |
| 13 | 2021-12-23 | Wagner (316) | 63 | 50 | Fairfield (204) | Final | L | -13 |
| 14 | 2021-12-31 | Manhattan (307) | 0 | 0 | Fairfield (204) | Postponed | - | - |
| 15 | 2022-01-07 | Marist (178) | 60 | 51 | Fairfield (204) | Final | L | -9 |
| 16 | 2022-01-09 | Fairfield (203) | 62 | 69 | Siena (263) | Final | L | -7 |
| 17 | 2022-01-11 | Iona (220) | 80 | 76 | Fairfield (204) | Final | L | -4 |
| 18 | 2022-01-16 | Fairfield (225) | 66 | 72 | Quinnipiac (221) | Final | L | -6 |
| 19 | 2022-01-20 | Monmouth (176) | 61 | 58 | Fairfield (204) | Final | L | -3 |
| 20 | 2022-01-23 | Fairfield (213) | 69 | 66 | Marist (205) | Final | W | 3 |
| 21 | 2022-01-28 | Fairfield (213) | 76 | 65 | Rider (302) | Final | W | 11 |
| 22 | 2022-02-04 | Fairfield (208) | 56 | 59 | Monmouth (117) | Final | L | -3 |
| 23 | 2022-02-06 | Siena (160) | 62 | 56 | Fairfield (204) | Final | L | -6 |
| 24 | 2022-02-09 | Quinnipiac (189) | 69 | 60 | Fairfield (204) | Final | L | -9 |
| 25 | 2022-02-12 | Niagara (342) | 53 | 73 | Fairfield (204) | Final | W | 20 |
| 26 | 2022-02-14 | Canisius (328) | 76 | 80 | Fairfield (204) | Final/OT | W | 4 |
| 27 | 2022-02-18 | Saint Peter's (177) | 70 | 59 | Fairfield (222) | Final | L | -11 |
| 28 | 2022-02-20 | Fairfield (235) | 58 | 76 | Iona (46) | Final | L | -18 |
| 29 | 2022-02-27 | Fairfield (226) | 66 | 62 | Manhattan (222) | Final | W | 4 |
| 30 | 2022-03-03 | Rider (263) | 59 | 65 | Fairfield (226) | Final | W | 6 |
| 31 | 2022-03-05 | Fairfield (226) | 41 | 57 | Saint Peter's (156) | Final | L | -16 |
| 32 | 2022-03-08 | Canisius (254) | 50 | 72 | Fairfield (224) | Final | W | 22 |
| 33 | 2022-03-09 | Fairfield (224) | 63 | 77 | Saint Peter's (145) | Final | L | -14 |