Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | La Verne | 38 | 103 | San Diego (251) | Final | W | 65 |
| 2 | 2021-11-12 | San Diego (246) | 75 | 68 | Nevada (67) | Final | W | 7 |
| 3 | 2021-11-13 | San Diego (251) | 75 | 68 | Nevada (91) | Final | W | 7 |
| 4 | 2021-11-15 | San Diego (57) | 70 | 75 | California (278) | Final (OT) | L | -5 |
| 5 | 2021-11-17 | UC-Riverside (292) | 62 | 74 | San Diego (246) | Final | W | 12 |
| 6 | 2021-11-19 | Cal State-Fullerton (194) | 57 | 55 | San Diego (246) | Final | L | -2 |
| 7 | 2021-11-25 | South Alabama (177) | 68 | 67 | San Diego (246) | Final | L | -1 |
| 8 | 2021-11-26 | Illinois-Chicago (139) | 52 | 64 | San Diego (246) | Final | W | 12 |
| 9 | 2021-11-28 | Cal State-Northridge (240) | 56 | 52 | San Diego (182) | Final | L | -4 |
| 10 | 2021-12-01 | San Diego (246) | 43 | 63 | Fresno State (153) | Final | L | -20 |
| 11 | 2021-12-05 | Cal Poly (303) | 51 | 52 | San Diego (182) | Final | W | 1 |
| 12 | 2021-12-11 | California Lutheran | 55 | 84 | San Diego (246) | Final | W | 29 |
| 13 | 2021-12-18 | San Diego (246) | 69 | 59 | Northern Arizona (324) | Final | W | 10 |
| 14 | 2021-12-20 | Long Beach State (278) | 0 | 0 | San Diego (246) | Cancelled | - | - |
| 15 | 2021-12-22 | San Diego (246) | 57 | 80 | UNLV (105) | Final | L | -23 |
| 16 | 2021-12-30 | Gonzaga (11) | 0 | 0 | San Diego (246) | Postponed | - | - |
| 17 | 2022-01-01 | San Diego (246) | 0 | 0 | Santa Clara (42) | Postponed | - | - |
| 18 | 2022-01-08 | San Diego (246) | 73 | 88 | San Francisco (122) | Final | L | -15 |
| 19 | 2022-01-10 | San Diego (207) | 72 | 62 | Pepperdine (257) | Final | W | 10 |
| 20 | 2022-01-13 | Portland (210) | 63 | 68 | San Diego (246) | Final/OT | W | 5 |
| 21 | 2022-01-15 | Loyola Marymount (184) | 65 | 70 | San Diego (246) | Final | W | 5 |
| 22 | 2022-01-20 | San Diego (246) | 71 | 79 | BYU (23) | Final | L | -8 |
| 23 | 2022-01-22 | San Diego (246) | 73 | 65 | Pacific (132) | Final | W | 8 |
| 24 | 2022-01-24 | San Diego (246) | 74 | 78 | Santa Clara (42) | Final/OT | L | -4 |
| 25 | 2022-01-27 | Pepperdine (283) | 56 | 64 | San Diego (246) | Final | W | 8 |
| 26 | 2022-01-29 | San Diego (246) | 69 | 65 | Loyola Marymount (184) | Final | W | 4 |
| 27 | 2022-02-03 | Gonzaga (11) | 92 | 62 | San Diego (246) | Final | L | -30 |
| 28 | 2022-02-05 | Santa Clara (42) | 79 | 66 | San Diego (246) | Final | L | -13 |
| 29 | 2022-02-10 | San Diego (246) | 57 | 86 | Saint Mary's (33) | Final | L | -29 |
| 30 | 2022-02-12 | Pacific (132) | 54 | 60 | San Diego (246) | Final | W | 6 |
| 31 | 2022-02-17 | San Diego (246) | 60 | 92 | Portland (210) | Final | L | -32 |
| 32 | 2022-02-24 | Saint Mary's (27) | 60 | 46 | San Diego (192) | Final | L | -14 |
| 33 | 2022-02-26 | San Francisco (38) | 78 | 62 | San Diego (192) | Final | L | -16 |
| 34 | 2022-03-03 | Pepperdine (287) | 67 | 74 | San Diego (196) | Final | W | 7 |
| 35 | 2022-03-04 | San Diego (196) | 55 | 73 | Portland (182) | Final | L | -18 |