Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Houston Baptist (331) | 48 | 92 | Texas (10) | Final | L | -44 |
| 2 | 2021-11-13 | Barclay | 44 | 122 | Houston Baptist (331) | Final | W | 78 |
| 3 | 2021-11-17 | Houston Baptist (235) | 39 | 73 | Texas A&M (36) | Final | L | -34 |
| 4 | 2021-11-21 | Houston Baptist (322) | 61 | 74 | Denver (349) | Final | L | -13 |
| 5 | 2021-11-24 | Houston Baptist (322) | 40 | 57 | Oklahoma (56) | Final | L | -17 |
| 6 | 2021-11-29 | Southwestern Adventist | 62 | 100 | Houston Baptist (321) | Final | W | 38 |
| 7 | 2021-12-04 | Oral Roberts (258) | 85 | 67 | Houston Baptist (321) | Final | L | -18 |
| 8 | 2021-12-07 | Champion Christian | 67 | 84 | Houston Baptist (322) | Final | W | 17 |
| 9 | 2021-12-11 | Rice (177) | 88 | 73 | Houston Baptist (322) | Final | L | -15 |
| 10 | 2021-12-21 | Houston Baptist | 0 | 0 | Florida International | Cancelled | - | - |
| 11 | 2022-01-03 | Ecclesia | 63 | 94 | Houston Baptist (318) | Final | W | 31 |
| 12 | 2022-01-06 | Southeastern Louisiana (305) | 90 | 81 | Houston Baptist (318) | Final | L | -9 |
| 13 | 2022-01-07 | Houston Baptist (318) | 65 | 81 | New Orleans (265) | Final | L | -16 |
| 14 | 2022-01-08 | Houston Baptist (318) | 50 | 60 | Incarnate Word (348) | Final | L | -10 |
| 15 | 2022-01-15 | Houston Baptist (343) | 75 | 78 | McNeese State (295) | Final | L | -3 |
| 16 | 2022-01-20 | Houston Baptist (345) | 68 | 65 | Incarnate Word (349) | Final | W | 3 |
| 17 | 2022-01-22 | Houston Baptist (345) | 77 | 71 | Texas A&M-Corpus Christi (163) | Final | W | 6 |
| 18 | 2022-01-27 | New Orleans (238) | 77 | 66 | Houston Baptist (327) | Final | L | -11 |
| 19 | 2022-01-29 | Nicholls State (215) | 73 | 61 | Houston Baptist (338) | Final | L | -12 |
| 20 | 2022-02-03 | Northwestern State (331) | 97 | 87 | Houston Baptist (338) | Final | L | -10 |
| 21 | 2022-02-05 | Southeastern Louisiana (268) | 80 | 93 | Houston Baptist (338) | Final | W | 13 |
| 22 | 2022-02-10 | Houston Baptist (333) | 76 | 69 | Northwestern State (319) | Final | W | 7 |
| 23 | 2022-02-12 | Houston Baptist (333) | 84 | 89 | Southeastern Louisiana (274) | Final | L | -5 |
| 24 | 2022-02-19 | Houston Baptist (325) | 70 | 84 | Nicholls State (207) | Final | L | -14 |
| 25 | 2022-02-24 | Incarnate Word (348) | 68 | 82 | Houston Baptist (329) | Final | W | 14 |
| 26 | 2022-02-26 | Texas A&M-Corpus Christi (252) | 75 | 70 | Houston Baptist (329) | Final | L | -5 |
| 27 | 2022-03-02 | Houston Baptist (327) | 74 | 75 | New Orleans (234) | Final | L | -1 |
| 28 | 2022-03-05 | McNeese State (308) | 144 | 149 | Houston Baptist (327) | Final | W | 5 |
| 29 | 2022-03-09 | Incarnate Word (348) | 64 | 74 | Houston Baptist (323) | Final | W | 10 |
| 30 | 2022-03-10 | Houston Baptist (323) | 60 | 75 | Texas A&M-Corpus Christi (245) | Final | L | -15 |