Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-12-04 | Oral Roberts (327) | 85 | 67 | Houston Christian (305) | Final | L | -18 |
| 2 | 2021-12-07 | Champion Christian | 67 | 84 | Houston Christian (305) | Final | W | 17 |
| 3 | 2021-12-11 | Rice (228) | 88 | 73 | Houston Christian (305) | Final | L | -15 |
| 4 | 2021-12-21 | Houston Christian (305) | 0 | 0 | Florida International (214) | Cancelled | - | - |
| 5 | 2022-01-03 | Ecclesia | 63 | 94 | Houston Christian (305) | Final | W | 31 |
| 6 | 2022-01-06 | Southeastern Louisiana (318) | 90 | 81 | Houston Christian (305) | Final | L | -9 |
| 7 | 2022-01-15 | Houston Christian (305) | 75 | 78 | McNeese (63) | Final | L | -3 |
| 8 | 2022-01-22 | Houston Christian (305) | 77 | 71 | Texas A&M-Corpus Christi (208) | Final | W | 6 |
| 9 | 2022-01-27 | New Orleans (236) | 77 | 66 | Houston Christian (305) | Final | L | -11 |
| 10 | 2022-01-29 | Nicholls State (250) | 73 | 61 | Houston Christian (305) | Final | L | -12 |
| 11 | 2022-02-03 | Northwestern State (315) | 97 | 87 | Houston Christian (305) | Final | L | -10 |
| 12 | 2022-02-05 | Southeastern Louisiana (318) | 80 | 93 | Houston Christian (305) | Final | W | 13 |