Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Rose-Hulman | 60 | 82 | Indiana State (120) | Final | W | 22 |
| 2 | 2021-11-09 | Indiana State (120) | 81 | 77 | Green Bay (280) | Final | W | 4 |
| 3 | 2021-11-12 | Indiana State (243) | 67 | 92 | Purdue (8) | Final | L | -25 |
| 4 | 2021-11-14 | Hanover | 49 | 90 | Indiana State (243) | Final | W | 41 |
| 5 | 2021-11-18 | Indiana State (187) | 77 | 36 | Old Dominion (240) | Final | W | 41 |
| 6 | 2021-11-19 | Oklahoma (47) | 87 | 63 | Indiana State (243) | Final | L | -24 |
| 7 | 2021-11-21 | New Mexico State (42) | 80 | 66 | Indiana State (171) | Final | L | -14 |
| 8 | 2021-11-27 | Indiana State (171) | 75 | 97 | Ball State (214) | Final | L | -22 |
| 9 | 2021-12-01 | Indiana State (243) | 76 | 88 | Loyola-Chicago (263) | Final | L | -12 |
| 10 | 2021-12-04 | Miami (OH) (40) | 68 | 69 | Indiana State (243) | Final | W | 1 |
| 11 | 2021-12-13 | Indiana State (243) | 70 | 77 | North Dakota State (117) | Final | L | -7 |
| 12 | 2021-12-18 | Alabama A&M (286) | 43 | 67 | Indiana State (243) | Final | W | 24 |
| 13 | 2021-12-20 | Oakland City | 69 | 78 | Indiana State (243) | Final | W | 9 |
| 14 | 2021-12-22 | Indiana State (243) | 0 | 0 | Northern Illinois (326) | Cancelled | - | - |
| 15 | 2021-12-29 | Midway | 51 | 107 | Indiana State (243) | Final | W | 56 |
| 16 | 2022-01-02 | Bradley (113) | 71 | 76 | Indiana State (243) | Final | W | 5 |
| 17 | 2022-01-05 | Evansville (302) | 0 | 0 | Indiana State (243) | Postponed | - | - |
| 18 | 2022-01-11 | Indiana State (243) | 74 | 80 | Northern Iowa (89) | Final/OT | L | -6 |
| 19 | 2022-01-15 | Loyola-Chicago (263) | 64 | 56 | Indiana State (243) | Final | L | -8 |
| 20 | 2022-01-19 | Indiana State (243) | 55 | 63 | Southern Illinois (150) | Final | L | -8 |
| 21 | 2022-01-22 | Valparaiso (156) | 75 | 73 | Indiana State (243) | Final | L | -2 |
| 22 | 2022-01-25 | Missouri State (75) | 72 | 76 | Indiana State (232) | Final | W | 4 |
| 23 | 2022-01-30 | Indiana State (219) | 52 | 67 | Bradley (144) | Final | L | -15 |
| 24 | 2022-02-02 | Drake (97) | 85 | 67 | Indiana State (219) | Final | L | -18 |
| 25 | 2022-02-05 | Indiana State (243) | 72 | 79 | Valparaiso (156) | Final/2OT | L | -7 |
| 26 | 2022-02-08 | Evansville (316) | 65 | 56 | Indiana State (235) | Final | L | -9 |
| 27 | 2022-02-10 | Indiana State (243) | 80 | 77 | Evansville (302) | Final/2OT | W | 3 |
| 28 | 2022-02-12 | Illinois State (94) | 57 | 60 | Indiana State (243) | Final | W | 3 |
| 29 | 2022-02-15 | Indiana State (242) | 70 | 79 | Missouri State (91) | Final | L | -9 |
| 30 | 2022-02-19 | Southern Illinois (187) | 76 | 72 | Indiana State (242) | Final | L | -4 |
| 31 | 2022-02-21 | Indiana State (243) | 58 | 74 | Drake (104) | Final | L | -16 |
| 32 | 2022-02-23 | Northern Iowa (113) | 88 | 82 | Indiana State (243) | Final | L | -6 |
| 33 | 2022-02-26 | Indiana State (243) | 66 | 86 | Illinois State (254) | Final | L | -20 |
| 34 | 2022-03-03 | Indiana State (260) | 53 | 58 | Illinois State (253) | Final | L | -5 |