Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Manhattanville | 42 | 99 | Manhattan (279) | Final | W | 57 |
| 2 | 2021-11-12 | Fordham (183) | 60 | 66 | Manhattan (307) | Final | W | 6 |
| 3 | 2021-11-15 | Manhattan (81) | 58 | 79 | Old Dominion (240) | Final | L | -21 |
| 4 | 2021-11-19 | North Alabama (335) | 51 | 55 | Manhattan (307) | Final | W | 4 |
| 5 | 2021-11-20 | Manhattan (307) | 76 | 60 | Liberty (93) | Final | W | 16 |
| 6 | 2021-11-30 | Fairleigh Dickinson (341) | 73 | 78 | Manhattan (109) | Final | W | 5 |
| 7 | 2021-12-03 | Manhattan (307) | 77 | 72 | Siena (160) | Final/OT | W | 5 |
| 8 | 2021-12-05 | Quinnipiac (250) | 90 | 73 | Manhattan (109) | Final | L | -17 |
| 9 | 2021-12-11 | Manhattan (307) | 62 | 96 | Utah (130) | Final | L | -34 |
| 10 | 2021-12-20 | Manhattan (307) | 99 | 75 | Charleston Southern (262) | Final | W | 24 |
| 11 | 2021-12-21 | Manhattan (307) | 77 | 74 | The Citadel (332) | Final | W | 3 |
| 12 | 2021-12-31 | Manhattan (307) | 0 | 0 | Fairfield (204) | Postponed | - | - |
| 13 | 2022-01-02 | Niagara (342) | 0 | 0 | Manhattan (307) | Postponed | - | - |
| 14 | 2022-01-07 | Manhattan (307) | 0 | 0 | Rider (356) | Postponed | - | - |
| 15 | 2022-01-14 | Manhattan (154) | 76 | 88 | Iona (45) | Final | L | -12 |
| 16 | 2022-01-16 | Canisius (277) | 75 | 80 | Manhattan (150) | Final | W | 5 |
| 17 | 2022-01-18 | Niagara (342) | 72 | 63 | Manhattan (307) | Final | L | -9 |
| 18 | 2022-01-21 | Siena (233) | 68 | 75 | Manhattan (150) | Final | W | 7 |
| 19 | 2022-01-23 | Manhattan (184) | 62 | 78 | Monmouth (104) | Final | L | -16 |
| 20 | 2022-01-28 | Manhattan (184) | 51 | 77 | Saint Peter's (209) | Final | L | -26 |
| 21 | 2022-01-30 | Marist (234) | 66 | 72 | Manhattan (192) | Final | W | 6 |
| 22 | 2022-02-04 | Manhattan (192) | 74 | 80 | Niagara (216) | Final (OT) | L | -6 |
| 23 | 2022-02-06 | Manhattan (307) | 70 | 77 | Canisius (328) | Final | L | -7 |
| 24 | 2022-02-08 | Manhattan (213) | 67 | 76 | Rider (285) | Final | L | -9 |
| 25 | 2022-02-11 | Monmouth (176) | 75 | 65 | Manhattan (307) | Final | L | -10 |
| 26 | 2022-02-13 | Manhattan (219) | 83 | 66 | Quinnipiac (233) | Final | W | 17 |
| 27 | 2022-02-20 | Rider (270) | 78 | 84 | Manhattan (207) | Final | W | 6 |
| 28 | 2022-02-25 | Manhattan (207) | 56 | 74 | Marist (200) | Final | L | -18 |
| 29 | 2022-02-27 | Fairfield (226) | 66 | 62 | Manhattan (222) | Final | L | -4 |
| 30 | 2022-03-01 | Saint Peter's (156) | 73 | 51 | Manhattan (222) | Final | L | -22 |
| 31 | 2022-03-03 | Iona (49) | 72 | 74 | Manhattan (222) | Final | W | 2 |
| 32 | 2022-03-08 | Rider (262) | 79 | 67 | Manhattan (217) | Final | L | -12 |