Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Eastern Illinois (308) | 56 | 80 | Northwestern (96) | Final | L | -24 |
| 2 | 2021-11-12 | Eastern Illinois (314) | 44 | 86 | Saint Louis (31) | Final | L | -42 |
| 3 | 2021-11-15 | Central Michigan (329) | 62 | 61 | Eastern Illinois (304) | Final | L | -1 |
| 4 | 2021-11-18 | Rockford | 64 | 96 | Eastern Illinois (304) | Final | W | 32 |
| 5 | 2021-11-22 | Eastern Illinois (314) | 43 | 82 | Eastern Kentucky (288) | Final | L | -39 |
| 6 | 2021-11-24 | Eastern Illinois (314) | 62 | 64 | Albany (330) | Final | L | -2 |
| 7 | 2021-11-28 | Evansville (313) | 70 | 54 | Eastern Illinois (356) | Final | L | -16 |
| 8 | 2021-12-01 | Eastern Illinois (314) | 45 | 55 | Northern Illinois (326) | Final | L | -10 |
| 9 | 2021-12-04 | North Park | 71 | 76 | Eastern Illinois (314) | Final | W | 5 |
| 10 | 2021-12-07 | Eastern Illinois (314) | 44 | 72 | Missouri (51) | Final | L | -28 |
| 11 | 2021-12-11 | Eastern Illinois (314) | 54 | 66 | Butler (80) | Final | L | -12 |
| 12 | 2021-12-18 | Eastern Illinois (314) | 54 | 71 | Western Illinois (362) | Final | L | -17 |
| 13 | 2021-12-21 | Eastern Illinois (314) | 55 | 75 | Ball State (298) | Final | L | -20 |
| 14 | 2021-12-29 | Eastern Illinois (314) | 50 | 63 | Morehead State (233) | Final | L | -13 |
| 15 | 2022-01-01 | Belmont (68) | 0 | 0 | Eastern Illinois (314) | Postponed | - | - |
| 16 | 2022-01-06 | Murray State (116) | 0 | 0 | Eastern Illinois (314) | Postponed | - | - |
| 17 | 2022-01-13 | SIU-Edwardsville (248) | 66 | 53 | Eastern Illinois (314) | Final | L | -13 |
| 18 | 2022-01-15 | Eastern Illinois (314) | 0 | 0 | Austin Peay (138) | Postponed | - | - |
| 19 | 2022-01-17 | Murray State (32) | 72 | 46 | Eastern Illinois (355) | Final | L | -26 |
| 20 | 2022-01-20 | Eastern Illinois (314) | 51 | 91 | Murray State (116) | Final | L | -40 |
| 21 | 2022-01-22 | Southeast Missouri State (226) | 87 | 58 | Eastern Illinois (314) | Final | L | -29 |
| 22 | 2022-01-24 | Belmont (68) | 90 | 56 | Eastern Illinois (314) | Final | L | -34 |
| 23 | 2022-01-27 | Eastern Illinois (314) | 58 | 53 | Tennessee-Martin (205) | Final | W | 5 |
| 24 | 2022-01-29 | Tennessee State (165) | 57 | 62 | Eastern Illinois (314) | Final | W | 5 |
| 25 | 2022-02-03 | Eastern Illinois (314) | 0 | 0 | SIU-Edwardsville (248) | Postponed | - | - |
| 26 | 2022-02-05 | Eastern Illinois (314) | 56 | 63 | Southeast Missouri State (226) | Final | L | -7 |
| 27 | 2022-02-07 | Eastern Illinois (314) | 58 | 84 | Tennessee Tech (310) | Final | L | -26 |
| 28 | 2022-02-10 | Tennessee Tech (310) | 73 | 62 | Eastern Illinois (314) | Final | L | -11 |
| 29 | 2022-02-12 | Tennessee-Martin (205) | 70 | 82 | Eastern Illinois (314) | Final | W | 12 |
| 30 | 2022-02-14 | Eastern Illinois (314) | 54 | 62 | Austin Peay (138) | Final | L | -8 |
| 31 | 2022-02-17 | Eastern Illinois (314) | 57 | 81 | Belmont (68) | Final | L | -24 |
| 32 | 2022-02-19 | Eastern Illinois (353) | 49 | 63 | Tennessee State (311) | Final | L | -14 |
| 33 | 2022-02-21 | Eastern Illinois (353) | 52 | 66 | SIU-Edwardsville (310) | Final | L | -14 |
| 34 | 2022-02-24 | Morehead State (131) | 82 | 46 | Eastern Illinois (353) | Final | L | -36 |
| 35 | 2022-02-26 | Austin Peay (275) | 64 | 52 | Eastern Illinois (353) | Final | L | -12 |