Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-03 | St. Katherine | 44 | 65 | San Diego State (11) | Final | W | 21 |
| 2 | 2021-11-09 | UC-Riverside (114) | 53 | 66 | San Diego State (11) | Final | W | 13 |
| 3 | 2021-11-12 | San Diego State (48) | 60 | 66 | BYU (23) | Final | L | -6 |
| 4 | 2021-11-18 | Arizona State (173) | 63 | 65 | San Diego State (139) | Final | W | 2 |
| 5 | 2021-11-20 | Texas-Arlington (162) | 62 | 68 | San Diego State (48) | Final | W | 6 |
| 6 | 2021-11-25 | Georgetown (83) | 56 | 73 | San Diego State (48) | Final | W | 17 |
| 7 | 2021-11-26 | USC (71) | 58 | 43 | San Diego State (48) | Final | L | -15 |
| 8 | 2021-11-26 | Georgetown (153) | 56 | 73 | San Diego State (99) | Final | W | 17 |
| 9 | 2021-11-30 | Long Beach State (281) | 47 | 72 | San Diego State (91) | Final | W | 25 |
| 10 | 2021-12-04 | San Diego State (48) | 58 | 72 | Michigan (1) | Final | L | -14 |
| 11 | 2021-12-08 | Cal State-Fullerton (184) | 56 | 66 | San Diego State (111) | Final | W | 10 |
| 12 | 2021-12-17 | San Diego State (48) | 63 | 53 | Saint Mary's (33) | Final | W | 10 |
| 13 | 2021-12-22 | UC-San Diego (126) | 57 | 78 | San Diego State (48) | Final | W | 21 |
| 14 | 2021-12-28 | San Diego Christian | 0 | 0 | San Diego State | Cancelled | - | - |
| 15 | 2022-01-01 | San Diego State (48) | 62 | 55 | UNLV (105) | Final | W | 7 |
| 16 | 2022-01-05 | Fresno State (153) | 0 | 0 | San Diego State (48) | Postponed | - | - |
| 17 | 2022-01-08 | Colorado State (85) | 49 | 79 | San Diego State (48) | Final | W | 30 |
| 18 | 2022-01-18 | UNLV (105) | 0 | 0 | San Diego State (48) | Postponed | - | - |
| 19 | 2022-01-22 | Boise State (62) | 42 | 37 | San Diego State (48) | Final | L | -5 |
| 20 | 2022-01-24 | UNLV (105) | 55 | 80 | San Diego State (48) | Final | W | 25 |
| 21 | 2022-01-26 | San Diego State (47) | 57 | 75 | Utah State (102) | Final | L | -18 |
| 22 | 2022-01-31 | New Mexico (173) | 47 | 72 | San Diego State (48) | Final | W | 25 |
| 23 | 2022-02-04 | San Diego State (48) | 57 | 58 | Colorado State (28) | Final | L | -1 |
| 24 | 2022-02-06 | Nevada (67) | 63 | 65 | San Diego State (48) | Final | W | 2 |
| 25 | 2022-02-09 | San Diego State (48) | 72 | 62 | San Jose State (229) | Final | W | 10 |
| 26 | 2022-02-12 | Air Force (347) | 64 | 76 | San Diego State (48) | Final | W | 12 |
| 27 | 2022-02-15 | Utah State (81) | 56 | 75 | San Diego State (41) | Final | W | 19 |
| 28 | 2022-02-19 | San Diego State (41) | 61 | 44 | Fresno State (86) | Final | W | 17 |
| 29 | 2022-02-22 | San Diego State (34) | 57 | 58 | Boise State (36) | Final | L | -1 |
| 30 | 2022-02-25 | San Jose State (241) | 52 | 77 | San Diego State (34) | Final | W | 25 |
| 31 | 2022-02-28 | San Diego State (36) | 73 | 66 | Wyoming (34) | Final | W | 7 |
| 32 | 2022-03-03 | Fresno State (87) | 64 | 65 | San Diego State (36) | Final | W | 1 |
| 33 | 2022-03-05 | San Diego State (36) | 79 | 78 | Nevada (126) | Final | W | 1 |
| 34 | 2022-03-10 | Fresno State (91) | 46 | 53 | San Diego State (28) | Final | W | 7 |
| 35 | 2022-03-12 | San Diego State (28) | 63 | 58 | Colorado State (19) | Final | W | 5 |
| 36 | 2022-03-12 | San Diego State (28) | 52 | 53 | Boise State (31) | Final | L | -1 |
| 37 | 2022-03-17 | Creighton (32) | 72 | 69 | San Diego State (27) | Final (OT) | L | -3 |