Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Florida National | 57 | 94 | Florida Gulf Coast (227) | Final | W | 37 |
| 2 | 2021-11-13 | Florida Gulf Coast (227) | 77 | 89 | Loyola-Chicago (27) | Final | L | -12 |
| 3 | 2021-11-16 | USC (22) | 78 | 61 | Florida Gulf Coast (222) | Final | L | -17 |
| 4 | 2021-11-21 | Eckerd | 59 | 99 | Florida Gulf Coast (220) | Final | W | 40 |
| 5 | 2021-11-23 | Rhode Island (59) | 66 | 67 | Florida Gulf Coast (220) | Final | W | 1 |
| 6 | 2021-11-26 | Western Michigan (304) | 67 | 77 | Florida Gulf Coast (241) | Final | W | 10 |
| 7 | 2021-11-27 | Southeastern Louisiana (283) | 71 | 90 | Florida Gulf Coast (220) | Final | W | 19 |
| 8 | 2021-11-28 | Purdue Fort Wayne (235) | 78 | 85 | Florida Gulf Coast (98) | Final | W | 7 |
| 9 | 2021-12-01 | Florida Gulf Coast (241) | 61 | 77 | Florida International (214) | Final | L | -16 |
| 10 | 2021-12-04 | Dartmouth (256) | 68 | 78 | Florida Gulf Coast (241) | Final/OT | W | 10 |
| 11 | 2021-12-07 | Florida Gulf Coast (241) | 69 | 55 | Florida A&M (297) | Final | W | 14 |
| 12 | 2021-12-11 | Florida Gulf Coast (241) | 85 | 74 | Robert Morris (148) | Final | W | 11 |
| 13 | 2021-12-19 | Mercer (174) | 55 | 67 | Florida Gulf Coast (241) | Final | W | 12 |
| 14 | 2021-12-22 | Florida Gulf Coast (241) | 90 | 97 | Canisius (328) | Final/OT | L | -7 |
| 15 | 2022-01-05 | North Florida (345) | 67 | 74 | Florida Gulf Coast (241) | Final | W | 7 |
| 16 | 2022-01-08 | Florida Gulf Coast (241) | 66 | 69 | Jacksonville (281) | Final | L | -3 |
| 17 | 2022-01-13 | Florida Gulf Coast (241) | 53 | 77 | Kennesaw State (142) | Final | L | -24 |
| 18 | 2022-01-15 | Liberty (93) | 78 | 75 | Florida Gulf Coast (241) | Final | L | -3 |
| 19 | 2022-01-18 | Florida Gulf Coast (241) | 93 | 91 | Stetson (301) | Final/OT | W | 2 |
| 20 | 2022-01-22 | Florida Gulf Coast (241) | 71 | 79 | Jacksonville State (227) | Final | L | -8 |
| 21 | 2022-01-27 | Eastern Kentucky (288) | 73 | 77 | Florida Gulf Coast (241) | Final | W | 4 |
| 22 | 2022-01-29 | Bellarmine (266) | 74 | 63 | Florida Gulf Coast (241) | Final | L | -11 |
| 23 | 2022-02-03 | Florida Gulf Coast (241) | 95 | 93 | Central Arkansas (143) | Final/OT | W | 2 |
| 24 | 2022-02-05 | Florida Gulf Coast (241) | 77 | 68 | Lipscomb (190) | Final | W | 9 |
| 25 | 2022-02-09 | North Alabama (335) | 60 | 92 | Florida Gulf Coast (241) | Final | W | 32 |
| 26 | 2022-02-12 | Stetson (301) | 82 | 89 | Florida Gulf Coast (241) | Final/OT | W | 7 |
| 27 | 2022-02-16 | Kennesaw State (252) | 76 | 82 | Florida Gulf Coast (181) | Final | W | 6 |
| 28 | 2022-02-19 | Florida Gulf Coast (181) | 64 | 70 | North Florida (283) | Final | L | -6 |
| 29 | 2022-02-23 | Florida Gulf Coast (188) | 82 | 72 | Liberty (120) | Final | W | 10 |
| 30 | 2022-02-26 | Jacksonville (171) | 69 | 76 | Florida Gulf Coast (188) | Final | W | 7 |
| 31 | 2022-03-01 | North Alabama (312) | 72 | 81 | Florida Gulf Coast (163) | Final | W | 9 |
| 32 | 2022-03-03 | Florida Gulf Coast (163) | 68 | 81 | Bellarmine (198) | Final | L | -13 |
| 33 | 2022-03-16 | Detroit (212) | 79 | 95 | Florida Gulf Coast (241) | Final | W | 16 |
| 34 | 2022-03-21 | Florida Gulf Coast (180) | 68 | 84 | Coastal Carolina (172) | Final | L | -16 |