Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Quinnipiac (249) | 69 | 83 | Maryland (40) | Final | L | -14 |
| 2 | 2021-11-12 | Western New England | 52 | 103 | Quinnipiac (189) | Final | W | 51 |
| 3 | 2021-11-15 | Holy Cross (220) | 68 | 76 | Quinnipiac (200) | Final | W | 8 |
| 4 | 2021-11-20 | Central Connecticut State (258) | 65 | 76 | Quinnipiac (189) | Final | W | 11 |
| 5 | 2021-11-23 | Quinnipiac (160) | 69 | 84 | New Hampshire (209) | Final | L | -15 |
| 6 | 2021-11-28 | Brown (211) | 72 | 61 | Quinnipiac (250) | Final | L | -11 |
| 7 | 2021-12-03 | Saint Peter's (200) | 69 | 59 | Quinnipiac (189) | Final | L | -10 |
| 8 | 2021-12-05 | Quinnipiac (250) | 90 | 73 | Manhattan (109) | Final | W | 17 |
| 9 | 2021-12-08 | Quinnipiac (229) | 72 | 69 | Dartmouth (211) | Final | W | 3 |
| 10 | 2021-12-11 | Maine (350) | 47 | 73 | Quinnipiac (189) | Final | W | 26 |
| 11 | 2021-12-22 | Quinnipiac (189) | 0 | 0 | Penn State (129) | Cancelled | - | - |
| 12 | 2021-12-31 | Niagara (342) | 68 | 77 | Quinnipiac (189) | Final | W | 9 |
| 13 | 2022-01-02 | Rider (356) | 0 | 0 | Quinnipiac (189) | Postponed | - | - |
| 14 | 2022-01-09 | Quinnipiac (220) | 66 | 76 | Niagara (202) | Final | L | -10 |
| 15 | 2022-01-11 | Quinnipiac (189) | 67 | 79 | Canisius (328) | Final | L | -12 |
| 16 | 2022-01-14 | Quinnipiac (220) | 77 | 70 | Rider (291) | Final (OT) | W | 7 |
| 17 | 2022-01-16 | Fairfield (225) | 66 | 72 | Quinnipiac (221) | Final | W | 6 |
| 18 | 2022-01-19 | Rider (356) | 67 | 73 | Quinnipiac (189) | Final | W | 6 |
| 19 | 2022-01-23 | Iona (40) | 76 | 61 | Quinnipiac (217) | Final | L | -15 |
| 20 | 2022-01-28 | Marist (205) | 87 | 94 | Quinnipiac (217) | Final | W | 7 |
| 21 | 2022-01-30 | Quinnipiac (220) | 76 | 85 | Siena (218) | Final | L | -9 |
| 22 | 2022-02-04 | Quinnipiac (220) | 74 | 83 | Saint Peter's (183) | Final | L | -9 |
| 23 | 2022-02-06 | Monmouth (176) | 76 | 63 | Quinnipiac (189) | Final | L | -13 |
| 24 | 2022-02-09 | Quinnipiac (189) | 69 | 60 | Fairfield (204) | Final | W | 9 |
| 25 | 2022-02-13 | Manhattan (219) | 83 | 66 | Quinnipiac (233) | Final | L | -17 |
| 26 | 2022-02-20 | Quinnipiac (234) | 66 | 67 | Marist (200) | Final | L | -1 |
| 27 | 2022-02-24 | Siena (197) | 78 | 71 | Quinnipiac (234) | Final | L | -7 |
| 28 | 2022-02-27 | Canisius (269) | 72 | 67 | Quinnipiac (244) | Final | L | -5 |
| 29 | 2022-03-03 | Quinnipiac (244) | 72 | 75 | Monmouth (128) | Final | L | -3 |
| 30 | 2022-03-05 | Quinnipiac (244) | 61 | 79 | Iona (49) | Final | L | -18 |
| 31 | 2022-03-08 | Quinnipiac (249) | 77 | 52 | Marist (214) | Final | W | 25 |
| 32 | 2022-03-10 | Quinnipiac (249) | 77 | 71 | Siena (204) | Final | W | 6 |
| 33 | 2022-03-11 | Quinnipiac (249) | 52 | 64 | Saint Peter's (145) | Final | L | -12 |