Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Ball State (191) | 71 | 82 | Georgia Southern (216) | Final | W | 11 |
| 2 | 2021-11-13 | Georgia Southern (216) | 53 | 41 | South Florida (164) | Final | W | 12 |
| 3 | 2021-11-16 | Bob Jones | 51 | 103 | Georgia Southern (23) | Final | W | 52 |
| 4 | 2021-11-20 | Hampton (260) | 66 | 86 | Georgia Southern (216) | Final | W | 20 |
| 5 | 2021-11-21 | Georgia Southern (97) | 52 | 70 | Wofford (87) | Final | L | -18 |
| 6 | 2021-11-26 | Georgia Southern (216) | 59 | 61 | Georgia Tech (158) | Final | L | -2 |
| 7 | 2021-12-01 | Georgia Southern (216) | 51 | 59 | Morehead State (233) | Final | L | -8 |
| 8 | 2021-12-08 | Carver Bible | 43 | 85 | Georgia Southern (172) | Final | W | 42 |
| 9 | 2021-12-11 | Georgia Southern (216) | 68 | 77 | Mercer (174) | Final | L | -9 |
| 10 | 2021-12-15 | Georgia Southern (216) | 69 | 66 | Campbell (191) | Final | W | 3 |
| 11 | 2021-12-18 | Covenant | 51 | 85 | Georgia Southern (216) | Final | W | 34 |
| 12 | 2021-12-22 | Georgia Southern (216) | 0 | 0 | Fordham (183) | Cancelled | - | - |
| 13 | 2021-12-30 | Georgia Southern (216) | 66 | 78 | Little Rock (321) | Final | L | -12 |
| 14 | 2022-01-01 | Georgia Southern (216) | 56 | 74 | Arkansas State (147) | Final | L | -18 |
| 15 | 2022-01-06 | Texas State (199) | 0 | 0 | Georgia Southern (216) | Canceled | - | - |
| 16 | 2022-01-08 | Texas-Arlington (162) | 73 | 74 | Georgia Southern (216) | Final/OT | W | 1 |
| 17 | 2022-01-13 | Georgia Southern (216) | 0 | 0 | Troy (127) | Canceled | - | - |
| 18 | 2022-01-15 | Georgia Southern (216) | 67 | 73 | South Alabama (177) | Final | L | -6 |
| 19 | 2022-01-20 | Coastal Carolina (188) | 76 | 72 | Georgia Southern (216) | Final | L | -4 |
| 20 | 2022-01-22 | Appalachian State (159) | 70 | 62 | Georgia Southern (216) | Final | L | -8 |
| 21 | 2022-01-27 | Georgia Southern (216) | 50 | 45 | Louisiana-Monroe (358) | Final | W | 5 |
| 22 | 2022-01-29 | Georgia Southern (216) | 66 | 65 | Louisiana (290) | Final | W | 1 |
| 23 | 2022-02-03 | South Alabama (177) | 57 | 58 | Georgia Southern (216) | Final | W | 1 |
| 24 | 2022-02-05 | Troy (127) | 61 | 52 | Georgia Southern (216) | Final | L | -9 |
| 25 | 2022-02-10 | Georgia Southern (216) | 61 | 65 | Appalachian State (159) | Final | L | -4 |
| 26 | 2022-02-12 | Georgia Southern (216) | 58 | 79 | Coastal Carolina (188) | Final | L | -21 |
| 27 | 2022-02-17 | Georgia Southern (216) | 63 | 79 | Georgia State (299) | Final | L | -16 |
| 28 | 2022-02-19 | Georgia State (197) | 58 | 49 | Georgia Southern (238) | Final | L | -9 |
| 29 | 2022-02-23 | Louisiana (214) | 82 | 69 | Georgia Southern (248) | Final | L | -13 |
| 30 | 2022-02-25 | Louisiana-Monroe (246) | 75 | 81 | Georgia Southern (248) | Final | W | 6 |
| 31 | 2022-03-03 | Georgia Southern (251) | 70 | 64 | Coastal Carolina (157) | Final | W | 6 |
| 32 | 2022-03-05 | Georgia Southern (251) | 60 | 73 | Appalachian State (145) | Final | L | -13 |