Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Simpson | 47 | 98 | South Dakota (201) | Final | W | 51 |
| 2 | 2021-11-11 | Air Force (306) | 53 | 59 | South Dakota (201) | Final | W | 6 |
| 3 | 2021-11-14 | South Dakota (275) | 50 | 99 | Drake (217) | Final | L | -49 |
| 4 | 2021-11-19 | Southern (259) | 68 | 71 | South Dakota (275) | Final | W | 3 |
| 5 | 2021-11-21 | Tennessee State (315) | 66 | 83 | South Dakota (123) | Final | W | 17 |
| 6 | 2021-11-23 | Presentation | 58 | 99 | South Dakota (123) | Final | W | 41 |
| 7 | 2021-11-27 | South Dakota (123) | 70 | 83 | Nebraska (145) | Final | L | -13 |
| 8 | 2021-11-30 | South Dakota (179) | 52 | 61 | San Jose State (221) | Final | L | -9 |
| 9 | 2021-12-03 | Waldorf | 37 | 93 | South Dakota (275) | Final | W | 56 |
| 10 | 2021-12-07 | South Dakota (275) | 69 | 74 | Northern Colorado (196) | Final | L | -5 |
| 11 | 2021-12-11 | Northern Arizona (324) | 71 | 76 | South Dakota (275) | Final/OT | W | 5 |
| 12 | 2021-12-15 | Bellarmine (266) | 64 | 78 | South Dakota (275) | Final | W | 14 |
| 13 | 2021-12-20 | Oral Roberts (327) | 82 | 73 | South Dakota (275) | Final | L | -9 |
| 14 | 2021-12-22 | UMKC (364) | 68 | 57 | South Dakota (275) | Final | L | -11 |
| 15 | 2021-12-30 | South Dakota (275) | 0 | 0 | North Dakota (251) | Postponed | - | - |
| 16 | 2022-01-01 | South Dakota (275) | 0 | 0 | North Dakota State (117) | Postponed | - | - |
| 17 | 2022-01-08 | South Dakota (275) | 65 | 84 | South Dakota State (268) | Final | L | -19 |
| 18 | 2022-01-10 | South Dakota (239) | 75 | 68 | North Dakota (345) | Final | W | 7 |
| 19 | 2022-01-13 | Denver (253) | 71 | 80 | South Dakota (275) | Final | W | 9 |
| 20 | 2022-01-15 | Nebraska-Omaha (272) | 70 | 105 | South Dakota (275) | Final | W | 35 |
| 21 | 2022-01-20 | South Dakota (275) | 0 | 0 | Western Illinois (362) | Postponed | - | - |
| 22 | 2022-01-22 | South Dakota (275) | 90 | 79 | St. Thomas (137) | Final | W | 11 |
| 23 | 2022-01-24 | South Dakota (275) | 75 | 72 | Western Illinois (362) | Final | W | 3 |
| 24 | 2022-01-27 | North Dakota State (117) | 74 | 62 | South Dakota (275) | Final/OT | L | -12 |
| 25 | 2022-01-29 | North Dakota (251) | 58 | 71 | South Dakota (275) | Final | W | 13 |
| 26 | 2022-02-05 | South Dakota State (268) | 89 | 79 | South Dakota (275) | Final | L | -10 |
| 27 | 2022-02-07 | South Dakota (275) | 74 | 76 | North Dakota State (117) | Final | L | -2 |
| 28 | 2022-02-10 | South Dakota (275) | 91 | 69 | Nebraska-Omaha (272) | Final | W | 22 |
| 29 | 2022-02-12 | South Dakota (275) | 84 | 76 | Denver (253) | Final | W | 8 |
| 30 | 2022-02-17 | St. Thomas (137) | 60 | 81 | South Dakota (275) | Final | W | 21 |
| 31 | 2022-02-19 | Western Illinois (218) | 65 | 78 | South Dakota (201) | Final | W | 13 |
| 32 | 2022-02-24 | South Dakota (190) | 63 | 72 | UMKC (193) | Final | L | -9 |
| 33 | 2022-02-26 | South Dakota (190) | 92 | 87 | Oral Roberts (142) | Final | W | 5 |
| 34 | 2022-03-06 | South Dakota (181) | 74 | 61 | UMKC (198) | Final | W | 13 |
| 35 | 2022-03-07 | South Dakota (181) | 60 | 83 | South Dakota State (52) | Final | L | -23 |