Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-27 | Illinois-Springfield | 80 | 92 | Western Illinois (320) | Final | W | 12 |
| 2 | 2021-11-02 | Monmouth (IL) | 34 | 88 | Western Illinois (320) | Final | W | 54 |
| 3 | 2021-11-09 | Western Illinois (320) | 75 | 74 | Nebraska (146) | Final | W | 1 |
| 4 | 2021-11-12 | Culver-Stockton | 69 | 91 | Western Illinois (362) | Final | W | 22 |
| 5 | 2021-11-16 | Iowa Wesleyan | 71 | 97 | Western Illinois (105) | Final | W | 26 |
| 6 | 2021-11-20 | Western Illinois (362) | 80 | 84 | DePaul (95) | Final | L | -4 |
| 7 | 2021-11-22 | Western Illinois (362) | 69 | 67 | Northern Kentucky (195) | Final | W | 2 |
| 8 | 2021-11-24 | Western Illinois (362) | 68 | 72 | Eastern Michigan (277) | Final | L | -4 |
| 9 | 2021-11-27 | Miami (OH) (51) | 67 | 79 | Western Illinois (144) | Final | W | 12 |
| 10 | 2021-12-01 | Ball State (298) | 80 | 93 | Western Illinois (362) | Final | W | 13 |
| 11 | 2021-12-04 | Tennessee-Martin (205) | 64 | 81 | Western Illinois (362) | Final | W | 17 |
| 12 | 2021-12-05 | Western Illinois (120) | 97 | 70 | Central Michigan (325) | Final | W | 27 |
| 13 | 2021-12-18 | Eastern Illinois (314) | 54 | 71 | Western Illinois (362) | Final | W | 17 |
| 14 | 2021-12-20 | Western Illinois (362) | 84 | 80 | Denver (253) | Final/OT | W | 4 |
| 15 | 2021-12-22 | Western Illinois (362) | 78 | 84 | Nebraska-Omaha (272) | Final | L | -6 |
| 16 | 2021-12-29 | Western Illinois (362) | 71 | 92 | Iowa (28) | Final | L | -21 |
| 17 | 2022-01-01 | Western Illinois (362) | 66 | 89 | St. Thomas (137) | Final | L | -23 |
| 18 | 2022-01-06 | UMKC (364) | 0 | 0 | Western Illinois (362) | Postponed | - | - |
| 19 | 2022-01-08 | Oral Roberts (327) | 87 | 86 | Western Illinois (362) | Final | L | -1 |
| 20 | 2022-01-13 | Western Illinois (362) | 73 | 68 | North Dakota (251) | Final | W | 5 |
| 21 | 2022-01-15 | Western Illinois (362) | 90 | 79 | North Dakota State (117) | Final/OT | W | 11 |
| 22 | 2022-01-20 | South Dakota (275) | 0 | 0 | Western Illinois (362) | Postponed | - | - |
| 23 | 2022-01-22 | South Dakota State (268) | 93 | 75 | Western Illinois (362) | Final | L | -18 |
| 24 | 2022-01-24 | South Dakota (275) | 75 | 72 | Western Illinois (362) | Final | L | -3 |
| 25 | 2022-01-29 | St. Thomas (137) | 52 | 81 | Western Illinois (362) | Final | W | 29 |
| 26 | 2022-01-31 | UMKC (226) | 83 | 75 | Western Illinois (204) | Final | L | -8 |
| 27 | 2022-02-03 | Western Illinois (362) | 90 | 85 | Oral Roberts (327) | Final | W | 5 |
| 28 | 2022-02-05 | Western Illinois (362) | 82 | 91 | UMKC (364) | Final | L | -9 |
| 29 | 2022-02-10 | North Dakota State (117) | 84 | 81 | Western Illinois (362) | Final/2OT | L | -3 |
| 30 | 2022-02-12 | North Dakota (251) | 68 | 70 | Western Illinois (362) | Final | W | 2 |
| 31 | 2022-02-17 | Western Illinois (362) | 66 | 91 | South Dakota State (268) | Final | L | -25 |
| 32 | 2022-02-19 | Western Illinois (218) | 65 | 78 | South Dakota (201) | Final | L | -13 |
| 33 | 2022-02-24 | Nebraska-Omaha (343) | 76 | 88 | Western Illinois (232) | Final | W | 12 |
| 34 | 2022-02-26 | Denver (320) | 83 | 77 | Western Illinois (232) | Final | L | -6 |
| 35 | 2022-03-06 | Western Illinois (235) | 68 | 80 | Oral Roberts (151) | Final | L | -12 |
| 36 | 2022-03-19 | Western Illinois (237) | 54 | 80 | UTEP (150) | Final | L | -26 |