Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Regis College | 51 | 98 | Holy Cross (197) | Final | W | 47 |
| 2 | 2021-11-12 | Holy Cross (334) | 55 | 85 | Boston College (151) | Final | L | -30 |
| 3 | 2021-11-15 | Holy Cross (220) | 68 | 76 | Quinnipiac (200) | Final | L | -8 |
| 4 | 2021-11-20 | Holy Cross (334) | 53 | 72 | Air Force (347) | Final | L | -19 |
| 5 | 2021-11-21 | Bryant (231) | 78 | 62 | Holy Cross (336) | Final | L | -16 |
| 6 | 2021-11-24 | Mt. St. Vincent | 52 | 95 | Holy Cross (336) | Final | W | 43 |
| 7 | 2021-11-27 | New Hampshire (209) | 70 | 55 | Holy Cross (336) | Final | L | -15 |
| 8 | 2021-12-01 | Holy Cross (334) | 67 | 73 | Central Connecticut State (258) | Final | L | -6 |
| 9 | 2021-12-04 | Holy Cross (334) | 65 | 84 | La Salle (237) | Final | L | -19 |
| 10 | 2021-12-08 | Holy Cross (344) | 59 | 74 | Fairfield (145) | Final | L | -15 |
| 11 | 2021-12-11 | Siena (160) | 72 | 59 | Holy Cross (334) | Final | L | -13 |
| 12 | 2021-12-19 | Holy Cross (334) | 54 | 62 | Harvard (181) | Final | L | -8 |
| 13 | 2021-12-22 | Holy Cross (334) | 0 | 0 | Saint Joseph's (99) | Cancelled | - | - |
| 14 | 2022-01-01 | Navy (149) | 70 | 56 | Holy Cross (334) | Final | L | -14 |
| 15 | 2022-01-04 | Holy Cross (334) | 70 | 79 | Loyola-Maryland (325) | Final | L | -9 |
| 16 | 2022-01-07 | Lafayette (323) | 74 | 79 | Holy Cross (334) | Final | W | 5 |
| 17 | 2022-01-10 | Holy Cross (349) | 69 | 77 | Lehigh (333) | Final | L | -8 |
| 18 | 2022-01-13 | American (249) | 0 | 0 | Holy Cross (334) | Postponed | - | - |
| 19 | 2022-01-19 | Holy Cross (334) | 0 | 0 | Lafayette (323) | Postponed | - | - |
| 20 | 2022-01-22 | Bucknell (336) | 68 | 65 | Holy Cross (334) | Final | L | -3 |
| 21 | 2022-01-26 | Holy Cross (351) | 49 | 67 | American (323) | Final | L | -18 |
| 22 | 2022-01-28 | Lehigh (309) | 65 | 67 | Holy Cross (351) | Final | W | 2 |
| 23 | 2022-01-31 | Holy Cross (348) | 75 | 70 | Boston University (191) | Final | W | 5 |
| 24 | 2022-02-05 | Holy Cross (334) | 69 | 65 | Army (339) | Final | W | 4 |
| 25 | 2022-02-07 | Holy Cross (334) | 60 | 87 | Colgate (239) | Final | L | -27 |
| 26 | 2022-02-09 | Loyola-Maryland (325) | 64 | 68 | Holy Cross (334) | Final | W | 4 |
| 27 | 2022-02-12 | Holy Cross (334) | 78 | 72 | Bucknell (336) | Final | W | 6 |
| 28 | 2022-02-14 | American (249) | 60 | 54 | Holy Cross (334) | Final | L | -6 |
| 29 | 2022-02-16 | Boston University (198) | 78 | 65 | Holy Cross (327) | Final | L | -13 |
| 30 | 2022-02-19 | Holy Cross (327) | 55 | 50 | Navy (159) | Final | W | 5 |
| 31 | 2022-02-21 | Holy Cross (326) | 61 | 84 | Lafayette (307) | Final | L | -23 |
| 32 | 2022-02-23 | Colgate (182) | 78 | 71 | Holy Cross (326) | Final | L | -7 |
| 33 | 2022-02-26 | Army (277) | 66 | 58 | Holy Cross (326) | Final | L | -8 |
| 34 | 2022-03-01 | American (330) | 69 | 63 | Holy Cross (337) | Final | L | -6 |