Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-03 | Cal State-Los Angeles | 70 | 87 | Cal Poly (322) | Final | W | 17 |
| 2 | 2021-11-09 | Westcliff | 53 | 86 | Cal Poly (322) | Final | W | 33 |
| 3 | 2021-11-12 | North Dakota State (117) | 60 | 57 | Cal Poly (238) | Final | L | -3 |
| 4 | 2021-11-15 | Sacramento State (258) | 58 | 57 | Cal Poly (243) | Final | L | -1 |
| 5 | 2021-11-19 | Cal Poly (238) | 57 | 87 | Santa Clara (42) | Final | L | -30 |
| 6 | 2021-11-22 | Nicholls State (250) | 75 | 72 | Cal Poly (238) | Final/OT | L | -3 |
| 7 | 2021-11-24 | Idaho (209) | 63 | 67 | Cal Poly (238) | Final | W | 4 |
| 8 | 2021-12-02 | Cal Poly (303) | 55 | 64 | California Baptist (116) | Final | L | -9 |
| 9 | 2021-12-05 | Cal Poly (303) | 51 | 52 | San Diego (182) | Final | L | -1 |
| 10 | 2021-12-11 | Cal Poly (238) | 61 | 58 | Portland State (192) | Final | W | 3 |
| 11 | 2021-12-13 | Cal Poly (238) | 77 | 78 | Portland (210) | Final | L | -1 |
| 12 | 2021-12-17 | Cal Poly (238) | 48 | 83 | Fresno State (153) | Final | L | -35 |
| 13 | 2021-12-22 | Cal Poly (238) | 0 | 0 | UCLA (30) | Cancelled | - | - |
| 14 | 2021-12-30 | Long Beach State (278) | 0 | 0 | Cal Poly (238) | Cancelled | - | - |
| 15 | 2022-01-01 | Cal State-Fullerton (194) | 0 | 0 | Cal Poly (238) | Canceled | - | - |
| 16 | 2022-01-06 | Cal Poly (238) | 0 | 0 | UC-Santa Barbara (171) | Canceled | - | - |
| 17 | 2022-01-08 | Cal Poly (238) | 55 | 68 | Cal State-Northridge (180) | Final | L | -13 |
| 18 | 2022-01-13 | UC-Riverside (292) | 57 | 46 | Cal Poly (238) | Final | L | -11 |
| 19 | 2022-01-15 | UC-Davis (170) | 74 | 82 | Cal Poly (238) | Final | W | 8 |
| 20 | 2022-01-18 | Cal Poly (238) | 60 | 73 | Cal State-Bakersfield (333) | Final | L | -13 |
| 21 | 2022-01-22 | Hawaii (109) | 69 | 56 | Cal Poly (238) | Final | L | -13 |
| 22 | 2022-01-27 | Cal Poly (238) | 59 | 55 | UC-San Diego (126) | Final | W | 4 |
| 23 | 2022-01-29 | Cal Poly (238) | 48 | 72 | UC-Irvine (119) | Final | L | -24 |
| 24 | 2022-02-03 | Cal Poly (238) | 50 | 61 | Cal State-Fullerton (194) | Final | L | -11 |
| 25 | 2022-02-05 | Cal Poly (238) | 65 | 78 | Long Beach State (278) | Final | L | -13 |
| 26 | 2022-02-10 | Cal State-Northridge (180) | 83 | 78 | Cal Poly (238) | Final/2OT | L | -5 |
| 27 | 2022-02-12 | UC-Santa Barbara (171) | 69 | 64 | Cal Poly (238) | Final | L | -5 |
| 28 | 2022-02-17 | Cal Poly (238) | 0 | 0 | UC-Davis (170) | Canceled | - | - |
| 29 | 2022-02-19 | Cal Poly (328) | 58 | 78 | UC-Riverside (189) | Final | L | -20 |
| 30 | 2022-02-22 | Cal State-Bakersfield (304) | 61 | 60 | Cal Poly (330) | Final | L | -1 |
| 31 | 2022-02-25 | Cal Poly (330) | 54 | 63 | Hawaii (187) | Final | L | -9 |
| 32 | 2022-03-03 | UC-Irvine (122) | 54 | 65 | Cal Poly (338) | Final | W | 11 |
| 33 | 2022-03-05 | UC-San Diego (261) | 76 | 80 | Cal Poly (338) | Final | W | 4 |
| 34 | 2022-03-08 | Cal Poly (315) | 53 | 63 | UC-Davis (239) | Final | L | -10 |