Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | Cal State-Dominguez Hills | 59 | 84 | UC-Irvine (106) | Final | W | 25 |
| 2 | 2021-11-09 | UC-Irvine (106) | 51 | 62 | New Mexico State (195) | Final | L | -11 |
| 3 | 2021-11-13 | Boise State (51) | 50 | 58 | UC-Irvine (106) | Final | W | 8 |
| 4 | 2021-11-16 | La Verne | 41 | 100 | UC-Irvine (143) | Final | W | 59 |
| 5 | 2021-11-20 | Pepperdine (283) | 48 | 82 | UC-Irvine (119) | Final | W | 34 |
| 6 | 2021-11-27 | UC-Irvine (63) | 69 | 64 | Santa Clara (23) | Final | W | 5 |
| 7 | 2021-12-03 | Bethesda | 54 | 86 | UC-Irvine (119) | Final | W | 32 |
| 8 | 2021-12-11 | UC-Irvine (119) | 55 | 63 | Fresno State (153) | Final | L | -8 |
| 9 | 2021-12-15 | UC-Irvine (119) | 61 | 66 | USC (71) | Final | L | -5 |
| 10 | 2021-12-19 | UC-Irvine (119) | 54 | 76 | Duquesne (121) | Final | L | -22 |
| 11 | 2021-12-21 | UC-Irvine (119) | 0 | 0 | Buffalo (219) | Cancelled | - | - |
| 12 | 2021-12-30 | Cal State-Northridge (180) | 0 | 0 | UC-Irvine (119) | Cancelled | - | - |
| 13 | 2022-01-01 | UC-Santa Barbara (171) | 0 | 0 | UC-Irvine (119) | Canceled | - | - |
| 14 | 2022-01-06 | UC-Irvine (119) | 0 | 0 | UC-Davis (170) | Canceled | - | - |
| 15 | 2022-01-08 | UC-Irvine (119) | 68 | 51 | UC-Riverside (292) | Final | W | 17 |
| 16 | 2022-01-11 | UC-San Diego (126) | 0 | 0 | UC-Irvine (119) | Canceled | - | - |
| 17 | 2022-01-13 | UC-Irvine (119) | 56 | 72 | Hawaii (109) | Final | L | -16 |
| 18 | 2022-01-14 | UC-Irvine (105) | 56 | 72 | Hawaii (248) | Final | L | -16 |
| 19 | 2022-01-20 | Cal State-Fullerton (194) | 65 | 63 | UC-Irvine (119) | Final | L | -2 |
| 20 | 2022-01-22 | UC-Irvine (119) | 67 | 73 | Long Beach State (278) | Final | L | -6 |
| 21 | 2022-01-27 | Cal State-Bakersfield (333) | 52 | 57 | UC-Irvine (119) | Final | W | 5 |
| 22 | 2022-01-29 | Cal Poly (238) | 48 | 72 | UC-Irvine (119) | Final | W | 24 |
| 23 | 2022-02-03 | UC-Irvine (119) | 53 | 52 | UC-Santa Barbara (171) | Final | W | 1 |
| 24 | 2022-02-05 | UC-Irvine (119) | 75 | 70 | Cal State-Northridge (180) | Final | W | 5 |
| 25 | 2022-02-10 | UC-Riverside (292) | 56 | 66 | UC-Irvine (119) | Final | W | 10 |
| 26 | 2022-02-12 | UC-Davis (170) | 0 | 0 | UC-Irvine (119) | Canceled | - | - |
| 27 | 2022-02-15 | UC-Irvine (138) | 56 | 50 | UC-San Diego (263) | Final | W | 6 |
| 28 | 2022-02-19 | Hawaii (185) | 52 | 77 | UC-Irvine (138) | Final | W | 25 |
| 29 | 2022-02-24 | UC-Irvine (124) | 64 | 66 | Cal State-Fullerton (166) | Final | L | -2 |
| 30 | 2022-02-27 | Long Beach State (152) | 72 | 77 | UC-Irvine (122) | Final | W | 5 |
| 31 | 2022-03-03 | UC-Irvine (122) | 54 | 65 | Cal Poly (338) | Final | L | -11 |
| 32 | 2022-03-05 | UC-Irvine (122) | 66 | 61 | Cal State-Bakersfield (304) | Final | W | 5 |
| 33 | 2022-03-10 | UC-Santa Barbara (194) | 78 | 69 | UC-Irvine (139) | Final | L | -9 |