Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Cornell | 76 | 69 | Binghamton (300) | Final | L | -7 |
| 2 | 2021-11-14 | Binghamton (359) | 72 | 60 | Sacred Heart (270) | Final | W | 12 |
| 3 | 2021-11-17 | Binghamton (359) | 77 | 85 | Columbia (193) | Final/OT | L | -8 |
| 4 | 2021-11-20 | Binghamton (359) | 63 | 87 | Connecticut (4) | Final | L | -24 |
| 5 | 2021-11-28 | Hartwick | 41 | 110 | Binghamton (241) | Final | W | 69 |
| 6 | 2021-12-01 | Binghamton (359) | 57 | 79 | Saint Joseph's (99) | Final | L | -22 |
| 7 | 2021-12-04 | Binghamton (359) | 63 | 68 | Boston University (267) | Final | L | -5 |
| 8 | 2021-12-08 | Marist (259) | 64 | 51 | Binghamton (285) | Final | L | -13 |
| 9 | 2021-12-11 | SUNY Oneonta | 55 | 79 | Binghamton (285) | Final | W | 24 |
| 10 | 2021-12-21 | Niagara (342) | 0 | 0 | Binghamton (359) | Cancelled | - | - |
| 11 | 2021-12-29 | Elmira | 0 | 0 | Binghamton (359) | Cancelled | - | - |
| 12 | 2022-01-02 | UMass-Lowell (319) | 63 | 68 | Binghamton (359) | Final | W | 5 |
| 13 | 2022-01-06 | Binghamton (359) | 88 | 79 | Albany (330) | Final | W | 9 |
| 14 | 2022-01-08 | NJIT (306) | 67 | 56 | Binghamton (359) | Final | L | -11 |
| 15 | 2022-01-16 | Binghamton (285) | 73 | 65 | Maine (353) | Final | W | 8 |
| 16 | 2022-01-19 | Stony Brook (213) | 74 | 71 | Binghamton (359) | Final | L | -3 |
| 17 | 2022-01-22 | Binghamton (359) | 68 | 57 | NJIT (306) | Final | W | 11 |
| 18 | 2022-01-24 | Hartford | 64 | 74 | Binghamton (359) | Final | W | 10 |
| 19 | 2022-01-26 | Binghamton (278) | 60 | 72 | Hartford (324) | Final | L | -12 |
| 20 | 2022-01-29 | UMBC (198) | 70 | 68 | Binghamton (359) | Final | L | -2 |
| 21 | 2022-02-02 | Binghamton (289) | 77 | 61 | Stony Brook (147) | Final | W | 16 |
| 22 | 2022-02-05 | Maine (350) | 60 | 69 | Binghamton (359) | Final | W | 9 |
| 23 | 2022-02-09 | Binghamton (359) | 51 | 82 | Vermont (225) | Final | L | -31 |
| 24 | 2022-02-12 | New Hampshire (346) | 69 | 60 | Binghamton (359) | Final | L | -9 |
| 25 | 2022-02-16 | Albany (276) | 68 | 67 | Binghamton (285) | Final | L | -1 |
| 26 | 2022-02-19 | Binghamton (285) | 78 | 64 | UMass-Lowell (244) | Final | W | 14 |
| 27 | 2022-02-23 | Vermont (83) | 66 | 49 | Binghamton (281) | Final | L | -17 |
| 28 | 2022-02-26 | Binghamton (281) | 62 | 66 | New Hampshire (255) | Final | L | -4 |
| 29 | 2022-03-01 | Binghamton (286) | 68 | 78 | UMBC (227) | Final | L | -10 |
| 30 | 2022-03-06 | Binghamton (284) | 72 | 69 | New Hampshire (241) | Final | W | 3 |
| 31 | 2022-03-09 | Binghamton (284) | 42 | 74 | Vermont (79) | Final | L | -32 |