Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Sacred Heart (235) | 86 | 81 | La Salle (219) | Final (OT) | W | 5 |
| 2 | 2021-11-11 | Sacred Heart (235) | 64 | 92 | Providence (79) | Final | L | -28 |
| 3 | 2021-11-14 | Binghamton (359) | 72 | 60 | Sacred Heart (270) | Final | L | -12 |
| 4 | 2021-11-16 | Fisher College | 49 | 109 | Sacred Heart (250) | Final | W | 60 |
| 5 | 2021-11-20 | Fairfield (204) | 71 | 61 | Sacred Heart (270) | Final | L | -10 |
| 6 | 2021-11-22 | Sacred Heart (270) | 72 | 75 | Stony Brook (213) | Final | L | -3 |
| 7 | 2021-11-30 | Sacred Heart (282) | 70 | 75 | NJIT (265) | Final | L | -5 |
| 8 | 2021-12-02 | Sacred Heart (282) | 74 | 67 | Lafayette (293) | Final | W | 7 |
| 9 | 2021-12-05 | Sacred Heart (282) | 66 | 79 | Brown (211) | Final | L | -13 |
| 10 | 2021-12-07 | Sacred Heart (270) | 62 | 72 | Rhode Island (145) | Final | L | -10 |
| 11 | 2021-12-13 | Sacred Heart (270) | 79 | 69 | Columbia (193) | Final | W | 10 |
| 12 | 2021-12-19 | Sacred Heart (270) | 62 | 70 | UMass-Lowell (319) | Final | L | -8 |
| 13 | 2021-12-22 | Hartford | 78 | 71 | Sacred Heart (270) | Final | L | -7 |
| 14 | 2021-12-29 | Long Island (175) | 65 | 69 | Sacred Heart (270) | Final | W | 4 |
| 15 | 2021-12-31 | Sacred Heart (270) | 82 | 85 | Bryant (349) | Final | L | -3 |
| 16 | 2022-01-06 | Sacred Heart (270) | 0 | 2 | Central Connecticut State (258) | Forfeit | L | -2 |
| 17 | 2022-01-08 | Sacred Heart (270) | 0 | 2 | Wagner (316) | Forfeit | L | -2 |
| 18 | 2022-01-15 | Fairleigh Dickinson (343) | 71 | 77 | Sacred Heart (270) | Final | W | 6 |
| 19 | 2022-01-17 | Central Connecticut State (332) | 66 | 74 | Sacred Heart (298) | Final | W | 8 |
| 20 | 2022-01-21 | Sacred Heart (298) | 59 | 98 | Mount St Mary's (299) | Final | L | -39 |
| 21 | 2022-01-23 | Sacred Heart (312) | 74 | 85 | St. Francis (PA) (317) | Final | L | -11 |
| 22 | 2022-01-27 | St. Francis (NY) | 71 | 66 | Sacred Heart (270) | Final | L | -5 |
| 23 | 2022-01-29 | Merrimack (134) | 0 | 0 | Sacred Heart (270) | Postponed | - | - |
| 24 | 2022-02-03 | Sacred Heart (270) | 75 | 79 | Long Island (175) | Final | L | -4 |
| 25 | 2022-02-05 | Sacred Heart (270) | 66 | 62 | St. Francis (NY) | Final/OT | W | 4 |
| 26 | 2022-02-10 | Bryant (349) | 99 | 86 | Sacred Heart (270) | Final | L | -13 |
| 27 | 2022-02-12 | Sacred Heart (270) | 75 | 82 | Fairleigh Dickinson (343) | Final | L | -7 |
| 28 | 2022-02-15 | Merrimack (284) | 70 | 63 | Sacred Heart (326) | Final | L | -7 |
| 29 | 2022-02-17 | Wagner (316) | 76 | 67 | Sacred Heart (270) | Final | L | -9 |
| 30 | 2022-02-19 | Sacred Heart (326) | 79 | 80 | Merrimack (284) | Final | L | -1 |
| 31 | 2022-02-24 | Mount St Mary's (289) | 65 | 77 | Sacred Heart (336) | Final | W | 12 |
| 32 | 2022-02-26 | St. Francis (PA) (335) | 68 | 80 | Sacred Heart (336) | Final | W | 12 |
| 33 | 2022-03-02 | Sacred Heart (323) | 75 | 82 | Long Island (247) | Final | L | -7 |