Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Columbia | 67 | 77 | Fordham (313) | Final | L | -10 |
| 2 | 2021-11-12 | Marist (178) | 82 | 67 | Columbia (193) | Final | L | -15 |
| 3 | 2021-11-17 | Binghamton (359) | 77 | 85 | Columbia (193) | Final/OT | W | 8 |
| 4 | 2021-11-20 | Mt. St. Vincent | 62 | 87 | Columbia (341) | Final | W | 25 |
| 5 | 2021-11-23 | Columbia (255) | 72 | 79 | Lehigh (350) | Final | L | -7 |
| 6 | 2021-11-26 | Columbia (193) | 60 | 73 | Boston College (151) | Final | L | -13 |
| 7 | 2021-11-29 | Lafayette (293) | 73 | 50 | Columbia (315) | Final | L | -23 |
| 8 | 2021-12-01 | Columbia (193) | 60 | 98 | UMBC (198) | Final | L | -38 |
| 9 | 2021-12-04 | Maine (350) | 66 | 77 | Columbia (193) | Final | W | 11 |
| 10 | 2021-12-06 | Columbia (337) | 61 | 89 | Colgate (213) | Final | L | -28 |
| 11 | 2021-12-11 | Columbia (193) | 59 | 60 | Albany (330) | Final | L | -1 |
| 12 | 2021-12-13 | Sacred Heart (270) | 79 | 69 | Columbia (193) | Final | L | -10 |
| 13 | 2021-12-28 | Maryland-Eastern Shore (353) | 0 | 0 | Columbia (193) | Cancelled | - | - |
| 14 | 2022-01-02 | Columbia (193) | 0 | 0 | Yale (81) | Postponed | - | - |
| 15 | 2022-01-07 | Columbia (193) | 69 | 84 | Princeton (271) | Final | L | -15 |
| 16 | 2022-01-08 | Columbia (193) | 73 | 69 | Penn (131) | Final | W | 4 |
| 17 | 2022-01-15 | Harvard (181) | 91 | 82 | Columbia (193) | Final | L | -9 |
| 18 | 2022-01-22 | Brown (295) | 93 | 74 | Columbia (193) | Final | L | -19 |
| 19 | 2022-01-25 | Columbia (343) | 72 | 83 | Yale (166) | Final | L | -11 |
| 20 | 2022-01-29 | Dartmouth (256) | 76 | 63 | Columbia (193) | Final | L | -13 |
| 21 | 2022-02-04 | Penn (209) | 81 | 66 | Columbia (344) | Final | L | -15 |
| 22 | 2022-02-05 | Princeton (271) | 85 | 63 | Columbia (193) | Final | L | -22 |
| 23 | 2022-02-09 | Columbia (193) | 75 | 88 | Cornell (187) | Final | L | -13 |
| 24 | 2022-02-12 | Yale (81) | 84 | 59 | Columbia (193) | Final | L | -25 |
| 25 | 2022-02-18 | Columbia (349) | 54 | 62 | Harvard (236) | Final | L | -8 |
| 26 | 2022-02-19 | Columbia (349) | 50 | 79 | Dartmouth (293) | Final | L | -29 |
| 27 | 2022-02-26 | Columbia (350) | 74 | 81 | Brown (226) | Final | L | -7 |
| 28 | 2022-03-05 | Cornell (188) | 78 | 64 | Columbia (350) | Final | L | -14 |