NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | New Hampshire (302) | 50 | 93 | Iowa (31) | Final | W | 43 |
| 2 | 2021-11-11 | Samford (256) | 54 | 91 | Iowa (9) | Final | W | 37 |
| 3 | 2021-11-14 | Iowa (31) | 82 | 61 | Northern Iowa (92) | Final | W | 21 |
| 4 | 2021-11-17 | Southern (282) | 67 | 87 | Iowa (3) | Final | W | 20 |
| 5 | 2021-11-21 | Drake (203) | 0 | 0 | Iowa (3) | Cancelled | - | - |
| 6 | 2021-11-25 | Iowa | Seton Hall | Cancelled | - | - | ||
| 7 | 2021-11-26 | Iowa (9) | 0 | 0 | USC (25) | Cancelled | - | - |
| 8 | 2021-12-02 | Iowa (41) | 64 | 79 | Duke (23) | Final | L | -15 |
| 9 | 2021-12-05 | Michigan State (103) | 61 | 88 | Iowa (41) | Final | W | 27 |
| 10 | 2021-12-08 | Iowa (37) | 70 | 77 | Iowa State (14) | Final | L | -7 |
| 11 | 2021-12-18 | Central Florida (150) | 61 | 69 | Iowa (9) | Final | W | 8 |
| 12 | 2021-12-21 | IUPUI (114) | 74 | 73 | Iowa (34) | Final | L | -1 |
| 13 | 2021-12-30 | Iowa (51) | 0 | 0 | Penn State (110) | Cancelled | - | - |
| 14 | 2022-01-02 | Evansville (272) | 56 | 93 | Iowa (9) | Final | W | 37 |
| 15 | 2022-01-02 | Illinois | Iowa | Postponed | - | - | ||
| 16 | 2022-01-06 | Northwestern (50) | 77 | 69 | Iowa (45) | Final | L | -8 |
| 17 | 2022-01-09 | Iowa (9) | 95 | 86 | Nebraska (36) | Final | W | 9 |
| 18 | 2022-01-13 | Iowa (9) | 79 | 66 | Purdue (84) | Final | W | 13 |
| 19 | 2022-01-16 | Nebraska (36) | 83 | 93 | Iowa (9) | Final | W | 10 |
| 20 | 2022-01-20 | Iowa (29) | 105 | 49 | Minnesota (96) | Final | W | 56 |
| 21 | 2022-01-23 | Illinois (29) | 56 | 82 | Iowa (9) | Final | W | 26 |
| 22 | 2022-01-23 | Indiana | Iowa | Postponed | - | - | ||
| 23 | 2022-01-25 | Iowa (26) | 107 | 79 | Penn State (119) | Final | W | 28 |
| 24 | 2022-01-28 | Iowa (26) | 72 | 67 | Northwestern (77) | Final/OT | W | 5 |
| 25 | 2022-01-31 | Ohio State (11) | 92 | 88 | Iowa (9) | Final | L | -4 |
| 26 | 2022-02-03 | Iowa (27) | 84 | 50 | Wisconsin (251) | Final | W | 34 |
| 27 | 2022-02-06 | Iowa (27) | 90 | 98 | Michigan (6) | Final | L | -8 |
| 28 | 2022-02-09 | Minnesota (17) | 78 | 88 | Iowa (9) | Final | W | 10 |
| 29 | 2022-02-12 | Illinois | Iowa | TBD | - | - | ||
| 30 | 2022-02-14 | Maryland (19) | 81 | 69 | Iowa (27) | Final | L | -12 |
| 31 | 2022-02-19 | Iowa (31) | 96 | 91 | Indiana (15) | Final | W | 5 |
| 32 | 2022-02-21 | Indiana (15) | 82 | 88 | Iowa (31) | Final | W | 6 |
| 33 | 2022-02-24 | Iowa (24) | 87 | 78 | Rutgers (161) | Final | W | 9 |
| 34 | 2022-02-27 | Michigan (12) | 80 | 104 | Iowa (24) | Final | W | 24 |
| 35 | 2022-03-04 | Northwestern (61) | 59 | 72 | Iowa (19) | Final | W | 13 |
| 36 | 2022-03-05 | Nebraska (29) | 66 | 83 | Iowa (19) | Final | W | 17 |
| 37 | 2022-03-06 | Indiana (20) | 67 | 74 | Iowa (19) | Final | W | 7 |
| 38 | 2022-03-18 | Illinois State (132) | 58 | 98 | Iowa (14) | Final | W | 40 |
| 39 | 2022-03-20 | Creighton (43) | 64 | 62 | Iowa (14) | Final | L | -2 |