NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Creighton (103) | 79 | 82 | Drake (71) | Final | L | -3 |
| 2 | 2021-11-13 | Nebraska-Omaha (244) | 51 | 71 | Creighton (103) | Final | W | 20 |
| 3 | 2021-11-17 | Creighton (213) | 62 | 67 | Nebraska (13) | Final | L | -5 |
| 4 | 2021-11-21 | South Dakota State (179) | 55 | 67 | Creighton (213) | Final | W | 12 |
| 5 | 2021-11-27 | Northern Iowa (71) | 72 | 79 | Creighton (142) | Final | W | 7 |
| 6 | 2021-12-03 | Georgetown (173) | 38 | 64 | Creighton (80) | Final | W | 26 |
| 7 | 2021-12-05 | Villanova (166) | 58 | 72 | Creighton (80) | Final | W | 14 |
| 8 | 2021-12-12 | Arizona State (90) | 62 | 69 | Creighton (52) | Final | W | 7 |
| 9 | 2021-12-16 | South Dakota (72) | 73 | 71 | Creighton (40) | Final | L | -2 |
| 10 | 2021-12-19 | Creighton (98) | 71 | 56 | Providence (147) | Final | W | 15 |
| 11 | 2021-12-21 | Creighton (42) | 81 | 72 | Arkansas (28) | Final | W | 9 |
| 12 | 2021-12-31 | Creighton (98) | 0 | 0 | Butler (157) | Postponed | - | - |
| 13 | 2022-01-02 | Creighton (98) | 67 | 51 | Xavier (190) | Final | W | 16 |
| 14 | 2022-01-07 | Marquette (74) | 45 | 62 | Creighton (35) | Final | W | 17 |
| 15 | 2022-01-09 | Creighton (98) | 55 | 63 | Connecticut (2) | Final | L | -8 |
| 16 | 2022-01-14 | Seton Hall (108) | 60 | 83 | Creighton (40) | Final | W | 23 |
| 17 | 2022-01-16 | St. John's (87) | 80 | 86 | Creighton (98) | Final | W | 6 |
| 18 | 2022-01-19 | Creighton (98) | 95 | 44 | Butler (157) | Final | W | 51 |
| 19 | 2022-01-21 | Creighton (36) | 80 | 70 | Georgetown (170) | Final | W | 10 |
| 20 | 2022-01-23 | Creighton (98) | 64 | 74 | Villanova (35) | Final | L | -10 |
| 21 | 2022-01-28 | Providence (136) | 71 | 95 | Creighton (41) | Final | W | 24 |
| 22 | 2022-02-02 | Connecticut (15) | 76 | 56 | Creighton (38) | Final | L | -20 |
| 23 | 2022-02-04 | Creighton (38) | 77 | 68 | DePaul (40) | Final | W | 9 |
| 24 | 2022-02-06 | Creighton (38) | 47 | 50 | Marquette (60) | Final | L | -3 |
| 25 | 2022-02-11 | Xavier (243) | 47 | 68 | Creighton (41) | Final | W | 21 |
| 26 | 2022-02-13 | Butler (331) | 49 | 96 | Creighton (41) | Final | W | 47 |
| 27 | 2022-02-18 | Creighton (39) | 107 | 59 | St. John's (141) | Final | W | 48 |
| 28 | 2022-02-20 | Creighton (39) | 97 | 91 | Seton Hall (85) | Final/2OT | W | 6 |
| 29 | 2022-02-27 | DePaul (44) | 90 | 84 | Creighton (37) | Final | L | -6 |
| 30 | 2022-03-05 | Seton Hall (79) | 66 | 65 | Creighton (39) | Final | L | -1 |
| 31 | 2022-03-18 | Creighton (43) | 84 | 74 | Colorado (32) | Final | W | 10 |
| 32 | 2022-03-20 | Creighton (43) | 64 | 62 | Iowa (14) | Final | W | 2 |
| 33 | 2022-03-25 | Creighton (43) | 76 | 68 | Iowa State (8) | Final | W | 8 |
| 34 | 2022-03-27 | Creighton (43) | 50 | 80 | South Carolina (1) | Final | L | -30 |