NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Morehead State (275) | 31 | 93 | Michigan State (40) | Final | W | 62 |
| 2 | 2021-11-14 | Niagara (269) | 65 | 89 | Michigan State (40) | Final | W | 24 |
| 3 | 2021-11-16 | Valparaiso (337) | 62 | 73 | Michigan State (27) | Final | W | 11 |
| 4 | 2021-11-19 | Bryant (322) | 60 | 100 | Michigan State (27) | Final | W | 40 |
| 5 | 2021-11-21 | Michigan State (27) | 68 | 71 | Fordham (24) | Final | L | -3 |
| 6 | 2021-11-23 | Michigan State (19) | 63 | 66 | St. Francis (NY) (284) | Final | L | -3 |
| 7 | 2021-11-26 | Michigan State (19) | 84 | 71 | Oakland (262) | Final | W | 13 |
| 8 | 2021-11-28 | Marshall (146) | 75 | 85 | Michigan State (80) | Final | W | 10 |
| 9 | 2021-12-02 | Notre Dame (13) | 76 | 71 | Michigan State (103) | Final | L | -5 |
| 10 | 2021-12-05 | Michigan State (103) | 61 | 88 | Iowa (41) | Final | L | -27 |
| 11 | 2021-12-09 | Illinois (163) | 60 | 75 | Michigan State (124) | Final | W | 15 |
| 12 | 2021-12-20 | Michigan State (120) | 84 | 85 | Florida Gulf Coast (38) | Final/2OT | L | -1 |
| 13 | 2021-12-21 | West Virginia (73) | 74 | 54 | Michigan State (128) | Final | L | -20 |
| 14 | 2021-12-30 | Nebraska (4) | 69 | 72 | Michigan State (135) | Final | W | 3 |
| 15 | 2022-01-03 | Michigan State (135) | 0 | 0 | Northwestern (50) | Postponed | - | - |
| 16 | 2022-01-09 | Purdue (84) | 69 | 59 | Michigan State (19) | Final | L | -10 |
| 17 | 2022-01-12 | Michigan State (19) | 83 | 89 | Ohio State (11) | Final | L | -6 |
| 18 | 2022-01-16 | Northwestern (142) | 46 | 65 | Michigan State (19) | Final | W | 19 |
| 19 | 2022-01-19 | Michigan State (19) | 0 | 0 | Indiana (53) | Postponed | - | - |
| 20 | 2022-01-23 | Minnesota (17) | 71 | 74 | Michigan State (19) | Final | W | 3 |
| 21 | 2022-01-27 | Michigan State (19) | 79 | 58 | Penn State (96) | Final | W | 21 |
| 22 | 2022-01-30 | Michigan State (83) | 61 | 45 | Rutgers (173) | Final | W | 16 |
| 23 | 2022-02-03 | Maryland (23) | 67 | 62 | Michigan State (75) | Final | L | -5 |
| 24 | 2022-02-06 | Michigan State (75) | 60 | 71 | Minnesota (101) | Final | L | -11 |
| 25 | 2022-02-10 | Michigan (6) | 57 | 63 | Michigan State (19) | Final | W | 6 |
| 26 | 2022-02-12 | Michigan State (81) | 58 | 76 | Indiana (11) | Final | L | -18 |
| 27 | 2022-02-16 | Michigan State (19) | 74 | 67 | Wisconsin (77) | Final | W | 7 |
| 28 | 2022-02-21 | Penn State (149) | 79 | 71 | Michigan State (78) | Final | L | -8 |
| 29 | 2022-02-24 | Michigan State (84) | 51 | 62 | Michigan (12) | Final | L | -11 |
| 30 | 2022-02-27 | Ohio State (28) | 61 | 55 | Michigan State (84) | Final | L | -6 |
| 31 | 2022-03-03 | Purdue (83) | 69 | 73 | Michigan State (86) | Final | W | 4 |
| 32 | 2022-03-04 | Michigan State (86) | 58 | 74 | Ohio State (25) | Final | L | -16 |