NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Illinois State (82) | 60 | 77 | Northern Illinois (143) | Final | L | -17 |
| 2 | 2021-11-13 | Illinois State (82) | 70 | 55 | St. Thomas | Final | W | 15 |
| 3 | 2021-11-17 | Purdue (67) | 76 | 64 | Illinois State (233) | Final | L | -12 |
| 4 | 2021-11-20 | Illinois State (233) | 52 | 54 | Tennessee-Martin (110) | Final | L | -2 |
| 5 | 2021-11-25 | Sacramento State | Illinois State | Cancelled | - | - | ||
| 6 | 2021-11-26 | Illinois State (136) | 55 | 67 | UC-Irvine (101) | Final | L | -12 |
| 7 | 2021-11-27 | Sacramento State (222) | 65 | 63 | Illinois State (272) | Final | L | -2 |
| 8 | 2021-12-01 | Missouri Baptist | 42 | 91 | Illinois State (304) | Final | W | 49 |
| 9 | 2021-12-05 | Dayton (79) | 78 | 67 | Illinois State (304) | Final | L | -11 |
| 10 | 2021-12-11 | Illinois State (298) | 80 | 71 | SIU-Edwardsville (169) | Final | W | 9 |
| 11 | 2021-12-16 | Illinois State (272) | 60 | 70 | Wisconsin (301) | Final | L | -10 |
| 12 | 2021-12-20 | Saint Louis (199) | 66 | 77 | Illinois State (272) | Final | W | 11 |
| 13 | 2022-01-01 | Bradley (259) | 57 | 64 | Illinois State (269) | Final | W | 7 |
| 14 | 2022-01-07 | Illinois State (258) | 66 | 58 | Indiana State (195) | Final | W | 8 |
| 15 | 2022-01-09 | Illinois State (136) | 87 | 68 | Evansville (272) | Final | W | 19 |
| 16 | 2022-01-13 | Valparaiso (360) | 49 | 65 | Illinois State (136) | Final | W | 16 |
| 17 | 2022-01-15 | Loyola-Chicago (138) | 50 | 68 | Illinois State (226) | Final | W | 18 |
| 18 | 2022-01-20 | Illinois State (192) | 47 | 56 | Southern Illinois (128) | Final | L | -9 |
| 19 | 2022-01-22 | Illinois State (192) | 52 | 51 | Missouri State (32) | Final | W | 1 |
| 20 | 2022-01-27 | Northern Iowa (132) | 74 | 67 | Illinois State (136) | Final | L | -7 |
| 21 | 2022-01-29 | Drake (107) | 58 | 70 | Illinois State (171) | Final | W | 12 |
| 22 | 2022-02-04 | Evansville (292) | 60 | 75 | Illinois State (161) | Final | W | 15 |
| 23 | 2022-02-06 | Indiana State (192) | 64 | 72 | Illinois State (161) | Final | W | 8 |
| 24 | 2022-02-10 | Illinois State (136) | 57 | 53 | Loyola-Chicago (175) | Final | W | 4 |
| 25 | 2022-02-12 | Illinois State (151) | 85 | 80 | Valparaiso (265) | Final | W | 5 |
| 26 | 2022-02-18 | Missouri State (47) | 75 | 69 | Illinois State (139) | Final | L | -6 |
| 27 | 2022-02-20 | Southern Illinois (86) | 65 | 49 | Illinois State (139) | Final | L | -16 |
| 28 | 2022-02-25 | Illinois State (136) | 62 | 104 | Drake (236) | Final | L | -42 |
| 29 | 2022-02-27 | Illinois State (147) | 63 | 70 | Northern Iowa (78) | Final | L | -7 |
| 30 | 2022-03-05 | Illinois State (164) | 62 | 53 | Bradley (307) | Final | W | 9 |
| 31 | 2022-03-11 | Loyola-Chicago (141) | 52 | 68 | Illinois State (167) | Final | W | 16 |
| 32 | 2022-03-12 | Illinois State (167) | 50 | 42 | Southern Illinois (89) | Final | W | 8 |
| 33 | 2022-03-13 | Illinois State (167) | 50 | 48 | Northern Iowa (75) | Final | W | 2 |
| 34 | 2022-03-18 | Illinois State (132) | 58 | 98 | Iowa (14) | Final | L | -40 |