NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Purdue (140) | 79 | 69 | Western Kentucky (212) | Final | W | 10 |
| 2 | 2021-11-14 | Western Michigan (227) | 62 | 70 | Purdue (140) | Final | W | 8 |
| 3 | 2021-11-17 | Purdue (67) | 76 | 64 | Illinois State (233) | Final | W | 12 |
| 4 | 2021-11-20 | Dayton (157) | 78 | 62 | Purdue (67) | Final | L | -16 |
| 5 | 2021-11-22 | Marshall (95) | 60 | 70 | Purdue (67) | Final | W | 10 |
| 6 | 2021-11-25 | Purdue (84) | 57 | 65 | West Virginia (15) | Final | L | -8 |
| 7 | 2021-11-27 | Florida State (13) | 61 | 66 | Purdue (88) | Final | W | 5 |
| 8 | 2021-12-01 | Georgia Tech (71) | 52 | 53 | Purdue (83) | Final | W | 1 |
| 9 | 2021-12-05 | Ohio State (25) | 70 | 53 | Purdue (83) | Final | L | -17 |
| 10 | 2021-12-08 | Purdue (92) | 71 | 86 | Maryland (23) | Final | L | -15 |
| 11 | 2021-12-12 | Denver (279) | 68 | 101 | Purdue (92) | Final | W | 33 |
| 12 | 2021-12-19 | Miami (OH) (74) | 76 | 82 | Purdue (84) | Final | W | 6 |
| 13 | 2021-12-21 | North Alabama (298) | 53 | 86 | Purdue (91) | Final | W | 33 |
| 14 | 2021-12-30 | Purdue (82) | 0 | 0 | Wisconsin (280) | Postponed | - | - |
| 15 | 2022-01-02 | Rutgers (158) | 58 | 60 | Purdue (84) | Final | W | 2 |
| 16 | 2022-01-09 | Purdue (84) | 69 | 59 | Michigan State (19) | Final | W | 10 |
| 17 | 2022-01-13 | Iowa (9) | 79 | 66 | Purdue (84) | Final | L | -13 |
| 18 | 2022-01-16 | Indiana (53) | 73 | 68 | Purdue (84) | Final/OT | L | -5 |
| 19 | 2022-01-20 | Purdue (63) | 89 | 67 | Illinois (211) | Final | W | 22 |
| 20 | 2022-01-24 | Purdue (63) | 66 | 79 | Michigan (11) | Final | L | -13 |
| 21 | 2022-01-27 | Minnesota (17) | 66 | 80 | Purdue (84) | Final | W | 14 |
| 22 | 2022-01-30 | Purdue (58) | 66 | 81 | Nebraska (25) | Final | L | -15 |
| 23 | 2022-02-04 | Northwestern (77) | 80 | 67 | Purdue (57) | Final | L | -13 |
| 24 | 2022-02-06 | Purdue (57) | 57 | 64 | Indiana (11) | Final | L | -7 |
| 25 | 2022-02-09 | Penn State (96) | 77 | 81 | Purdue (84) | Final | W | 4 |
| 26 | 2022-02-13 | Purdue (68) | 52 | 54 | Wisconsin (236) | Final | L | -2 |
| 27 | 2022-02-17 | Illinois (227) | 54 | 70 | Purdue (73) | Final | W | 16 |
| 28 | 2022-02-20 | Purdue (73) | 70 | 59 | Rutgers (172) | Final | W | 11 |
| 29 | 2022-02-24 | Purdue (72) | 51 | 68 | Northwestern (60) | Final | L | -17 |
| 30 | 2022-02-27 | Wisconsin (221) | 63 | 62 | Purdue (72) | Final | L | -1 |
| 31 | 2022-03-03 | Purdue (83) | 69 | 73 | Michigan State (86) | Final | L | -4 |
| 32 | 2022-03-16 | Southern Illinois (92) | 60 | 82 | Purdue (84) | Final | W | 22 |
| 33 | 2022-03-21 | Purdue (84) | 62 | 77 | Marquette (67) | Final | L | -15 |