NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-11 | Samford (256) | 54 | 91 | Iowa (9) | Final | L | -37 |
| 2 | 2021-11-14 | Montevallo | 50 | 75 | Samford (157) | Final | W | 25 |
| 3 | 2021-11-17 | Jacksonville State (258) | 56 | 53 | Samford (237) | Final | L | -3 |
| 4 | 2021-11-20 | Samford (237) | 66 | 71 | Southern Miss (120) | Final | L | -5 |
| 5 | 2021-11-22 | Samford (237) | 48 | 81 | Colorado (25) | Final | L | -33 |
| 6 | 2021-11-26 | Samford (256) | 49 | 64 | Northern Colorado (149) | Final | L | -15 |
| 7 | 2021-12-01 | Samford (323) | 61 | 65 | Troy (188) | Final | L | -4 |
| 8 | 2021-12-04 | Murray State (52) | 66 | 75 | Samford (256) | Final | W | 9 |
| 9 | 2021-12-06 | Talladega | 70 | 88 | Samford (323) | Final | W | 18 |
| 10 | 2021-12-09 | Alabama A&M (341) | 72 | 47 | Samford (288) | Final | L | -25 |
| 11 | 2021-12-12 | UAB (244) | 68 | 77 | Samford (288) | Final | W | 9 |
| 12 | 2021-12-17 | Samford (290) | 48 | 73 | Ole Miss (44) | Final | L | -25 |
| 13 | 2021-12-21 | Samford (280) | 0 | 0 | Tennessee Tech (190) | Cancelled | - | - |
| 14 | 2021-12-27 | Samford (280) | 47 | 83 | LSU (13) | Final | L | -36 |
| 15 | 2021-12-29 | Kennesaw State (251) | 0 | 0 | Samford (282) | Cancelled | - | - |
| 16 | 2021-12-30 | Samford (282) | 78 | 75 | North Alabama (304) | Final/OT | W | 3 |
| 17 | 2022-01-06 | Chattanooga (321) | 0 | 0 | Samford (271) | Postponed | - | - |
| 18 | 2022-01-08 | East Tennessee State (212) | 0 | 0 | Samford (256) | Postponed | - | - |
| 19 | 2022-01-10 | Chattanooga (187) | 71 | 69 | Samford (256) | Final/2OT | L | -2 |
| 20 | 2022-01-13 | Samford (256) | 62 | 47 | Western Carolina (353) | Final | W | 15 |
| 21 | 2022-01-15 | Samford (286) | 62 | 57 | UNC-Greensboro (301) | Final | W | 5 |
| 22 | 2022-01-20 | Wofford (236) | 80 | 69 | Samford (261) | Final | L | -11 |
| 23 | 2022-01-22 | Furman (260) | 81 | 90 | Samford (261) | Final | W | 9 |
| 24 | 2022-01-29 | Samford (261) | 66 | 73 | Mercer (132) | Final | L | -7 |
| 25 | 2022-02-03 | Samford (263) | 69 | 76 | East Tennessee State (338) | Final | L | -7 |
| 26 | 2022-02-05 | Samford (256) | 77 | 67 | Chattanooga (187) | Final | W | 10 |
| 27 | 2022-02-07 | East Tennessee State (212) | 61 | 73 | Samford (256) | Final | W | 12 |
| 28 | 2022-02-10 | UNC-Greensboro (254) | 57 | 73 | Samford (256) | Final | W | 16 |
| 29 | 2022-02-12 | Western Carolina (339) | 51 | 64 | Samford (266) | Final | W | 13 |
| 30 | 2022-02-17 | Samford (261) | 67 | 79 | Furman (253) | Final | L | -12 |
| 31 | 2022-02-19 | Samford (261) | 52 | 60 | Wofford (199) | Final | L | -8 |
| 32 | 2022-02-26 | Mercer (107) | 64 | 55 | Samford (266) | Final | L | -9 |
| 33 | 2022-03-03 | UNC-Greensboro (309) | 40 | 59 | Samford (270) | Final | W | 19 |
| 34 | 2022-03-04 | Samford (270) | 35 | 65 | Mercer (106) | Final | L | -30 |