NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Creighton (103) | 79 | 82 | Drake (71) | Final | W | 3 |
| 2 | 2021-11-15 | South Dakota (45) | 61 | 46 | Drake (71) | Final | L | -15 |
| 3 | 2021-11-18 | Iowa State (37) | 98 | 76 | Drake (236) | Final | L | -22 |
| 4 | 2021-11-21 | Drake (203) | 0 | 0 | Iowa (3) | Cancelled | - | - |
| 5 | 2021-11-26 | Drake | San Francisco | Cancelled | - | - | ||
| 6 | 2021-11-26 | Drake (236) | 77 | 75 | Nevada (252) | Final | W | 2 |
| 7 | 2021-11-27 | San Francisco (114) | 60 | 84 | Drake (185) | Final | W | 24 |
| 8 | 2021-11-28 | Drake (185) | 83 | 66 | Idaho (237) | Final | W | 17 |
| 9 | 2021-12-03 | Longwood (149) | 82 | 104 | Drake (87) | Final | W | 22 |
| 10 | 2021-12-07 | Simpson | 57 | 101 | Drake (70) | Final | W | 44 |
| 11 | 2021-12-12 | Northern Illinois (191) | 44 | 96 | Drake (70) | Final | W | 52 |
| 12 | 2021-12-19 | Drake (236) | 68 | 89 | Nebraska (36) | Final | L | -21 |
| 13 | 2021-12-23 | Minnesota (68) | 63 | 77 | Drake (63) | Final | W | 14 |
| 14 | 2021-12-30 | Indiana State (235) | 78 | 70 | Drake (48) | Final | L | -8 |
| 15 | 2022-01-01 | Evansville (232) | 54 | 97 | Drake (48) | Final | W | 43 |
| 16 | 2022-01-07 | Drake (58) | 46 | 63 | Loyola-Chicago (155) | Final | L | -17 |
| 17 | 2022-01-09 | Drake (236) | 61 | 71 | Valparaiso (360) | Final | L | -10 |
| 18 | 2022-01-13 | Southern Illinois (291) | 60 | 49 | Drake (236) | Final | L | -11 |
| 19 | 2022-01-15 | Missouri State (22) | 69 | 53 | Drake (109) | Final | L | -16 |
| 20 | 2022-01-21 | Northern Iowa (66) | 57 | 65 | Drake (120) | Final | W | 8 |
| 21 | 2022-01-27 | Drake (236) | 80 | 56 | Bradley (155) | Final | W | 24 |
| 22 | 2022-01-29 | Drake (107) | 58 | 70 | Illinois State (171) | Final | L | -12 |
| 23 | 2022-02-04 | Valparaiso (278) | 72 | 65 | Drake (110) | Final | L | -7 |
| 24 | 2022-02-06 | Loyola-Chicago (150) | 76 | 84 | Drake (110) | Final | W | 8 |
| 25 | 2022-02-11 | Drake (115) | 59 | 63 | Missouri State (53) | Final | L | -4 |
| 26 | 2022-02-13 | Drake (115) | 65 | 73 | Southern Illinois (105) | Final | L | -8 |
| 27 | 2022-02-19 | Drake (118) | 73 | 68 | Northern Iowa (74) | Final | W | 5 |
| 28 | 2022-02-25 | Illinois State (136) | 62 | 104 | Drake (236) | Final | W | 42 |
| 29 | 2022-02-27 | Bradley (308) | 71 | 77 | Drake (112) | Final | W | 6 |
| 30 | 2022-03-03 | Drake (100) | 80 | 71 | Evansville (300) | Final/OT | W | 9 |
| 31 | 2022-03-05 | Drake (100) | 86 | 71 | Indiana State (241) | Final | W | 15 |
| 32 | 2022-03-10 | Bradley (306) | 56 | 71 | Drake (99) | Final | W | 15 |
| 33 | 2022-03-11 | Drake (99) | 49 | 63 | Missouri State (48) | Final | L | -14 |
| 34 | 2022-03-17 | Drake (102) | 83 | 78 | Missouri (46) | Final/OT | W | 5 |
| 35 | 2022-03-21 | Northern Iowa (76) | 55 | 62 | Drake (102) | Final | W | 7 |
| 36 | 2022-03-24 | Drake (102) | 66 | 84 | South Dakota State (53) | Final | L | -18 |