NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Winthrop (330) | 39 | 95 | Duke (73) | Final | W | 56 |
| 2 | 2021-11-12 | Duke (8) | 70 | 56 | Dayton (141) | Final | W | 14 |
| 3 | 2021-11-14 | UNC-Wilmington (259) | 45 | 87 | Duke (73) | Final | W | 42 |
| 4 | 2021-11-21 | Alabama (117) | 71 | 74 | Duke (11) | Final | W | 3 |
| 5 | 2021-11-24 | Appalachian State (227) | 65 | 73 | Duke (17) | Final | W | 8 |
| 6 | 2021-11-28 | Troy (169) | 75 | 91 | Duke (17) | Final | W | 16 |
| 7 | 2021-12-02 | Iowa (41) | 64 | 79 | Duke (23) | Final | W | 15 |
| 8 | 2021-12-05 | Duke (23) | 77 | 55 | Penn (143) | Final | W | 22 |
| 9 | 2021-12-15 | South Carolina (1) | 55 | 46 | Duke (15) | Final | L | -9 |
| 10 | 2021-12-19 | Duke (8) | 0 | 0 | Miami (64) | Postponed | - | - |
| 11 | 2021-12-21 | Duke (15) | 78 | 35 | Charleston Southern (356) | Final | W | 43 |
| 12 | 2021-12-30 | Duke (20) | 55 | 77 | Virginia Tech (37) | Final | L | -22 |
| 13 | 2022-01-02 | Notre Dame (20) | 70 | 72 | Duke (8) | Final | W | 2 |
| 14 | 2022-01-06 | Georgia Tech (32) | 0 | 0 | Duke (23) | Postponed | - | - |
| 15 | 2022-01-09 | Duke (8) | 74 | 65 | Syracuse (34) | Final | W | 9 |
| 16 | 2022-01-13 | Virginia Tech (39) | 65 | 54 | Duke (8) | Final | L | -11 |
| 17 | 2022-01-16 | Duke (8) | 60 | 84 | North Carolina State (27) | Final | L | -24 |
| 18 | 2022-01-18 | Duke (31) | 58 | 49 | Miami (67) | Final | W | 9 |
| 19 | 2022-01-23 | Virginia (38) | 48 | 57 | Duke (8) | Final | W | 9 |
| 20 | 2022-01-27 | North Carolina (14) | 78 | 62 | Duke (8) | Final | L | -16 |
| 21 | 2022-01-30 | Duke (27) | 65 | 77 | Louisville (5) | Final | L | -12 |
| 22 | 2022-02-01 | Georgia Tech (25) | 59 | 46 | Duke (34) | Final | L | -13 |
| 23 | 2022-02-03 | Duke (34) | 54 | 39 | Pittsburgh (86) | Final | W | 15 |
| 24 | 2022-02-06 | Wake Forest (88) | 76 | 81 | Duke (34) | Final | W | 5 |
| 25 | 2022-02-10 | Florida State (129) | 59 | 56 | Duke (8) | Final | L | -3 |
| 26 | 2022-02-13 | North Carolina State (2) | 77 | 62 | Duke (33) | Final | L | -15 |
| 27 | 2022-02-17 | Duke (38) | 54 | 67 | Virginia (232) | Final | L | -13 |
| 28 | 2022-02-20 | Duke (38) | 64 | 61 | Clemson (120) | Final | W | 3 |
| 29 | 2022-02-24 | Boston College (52) | 67 | 51 | Duke (43) | Final | L | -16 |
| 30 | 2022-02-27 | Duke (43) | 46 | 74 | North Carolina (9) | Final | L | -28 |
| 31 | 2022-03-02 | Pittsburgh (112) | 52 | 55 | Duke (50) | Final | W | 3 |
| 32 | 2022-03-03 | Duke (50) | 55 | 61 | Miami (53) | Final | L | -6 |