NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Illinois-Chicago (315) | 49 | 72 | Northwestern (38) | Final | W | 23 |
| 2 | 2021-11-14 | UC-Santa Barbara (234) | 46 | 72 | Northwestern (38) | Final | W | 26 |
| 3 | 2021-11-17 | Loyola-Chicago (206) | 47 | 63 | Northwestern (41) | Final | W | 16 |
| 4 | 2021-11-21 | Northwestern (41) | 75 | 78 | DePaul (61) | Final | L | -3 |
| 5 | 2021-11-25 | South Dakota (112) | 57 | 73 | Northwestern (142) | Final | W | 16 |
| 6 | 2021-11-26 | Northwestern (142) | 60 | 72 | Pittsburgh (279) | Final | L | -12 |
| 7 | 2021-11-27 | Northwestern (65) | 68 | 77 | Texas A&M (3) | Final | L | -9 |
| 8 | 2021-12-02 | Northwestern (84) | 72 | 61 | Clemson (72) | Final | W | 11 |
| 9 | 2021-12-05 | Wisconsin (313) | 49 | 61 | Northwestern (84) | Final | W | 12 |
| 10 | 2021-12-11 | Delaware (112) | 53 | 76 | Northwestern (64) | Final | W | 23 |
| 11 | 2021-12-14 | Milwaukee (234) | 46 | 55 | Northwestern (58) | Final | W | 9 |
| 12 | 2021-12-17 | Temple (136) | 58 | 68 | Northwestern (57) | Final | W | 10 |
| 13 | 2021-12-21 | Oregon (39) | 0 | 0 | Northwestern (50) | Cancelled | - | - |
| 14 | 2021-12-31 | Northwestern (142) | 0 | 0 | Minnesota (17) | Postponed | - | - |
| 15 | 2022-01-03 | Michigan State (135) | 0 | 0 | Northwestern (50) | Postponed | - | - |
| 16 | 2022-01-06 | Northwestern (50) | 77 | 69 | Iowa (45) | Final | W | 8 |
| 17 | 2022-01-09 | Ohio State (11) | 74 | 61 | Northwestern (142) | Final | L | -13 |
| 18 | 2022-01-13 | Rutgers (158) | 63 | 68 | Northwestern (142) | Final | W | 5 |
| 19 | 2022-01-16 | Northwestern (142) | 46 | 65 | Michigan State (19) | Final | L | -19 |
| 20 | 2022-01-20 | Penn State (114) | 63 | 59 | Northwestern (60) | Final | L | -4 |
| 21 | 2022-01-23 | Northwestern (142) | 59 | 87 | Maryland (18) | Final | L | -28 |
| 22 | 2022-01-28 | Iowa (26) | 72 | 67 | Northwestern (77) | Final/OT | L | -5 |
| 23 | 2022-01-30 | Illinois (206) | 0 | 0 | Northwestern (77) | Postponed | - | - |
| 24 | 2022-02-04 | Northwestern (77) | 80 | 67 | Purdue (57) | Final | W | 13 |
| 25 | 2022-02-06 | Northwestern (77) | 78 | 72 | Penn State (129) | Final | W | 6 |
| 26 | 2022-02-10 | Rutgers | Northwestern | Cancelled | - | - | ||
| 27 | 2022-02-13 | Michigan (5) | 69 | 71 | Northwestern (70) | Final/2OT | W | 2 |
| 28 | 2022-02-17 | Northwestern (59) | 58 | 69 | Indiana (15) | Final | L | -11 |
| 29 | 2022-02-20 | Northwestern (59) | 82 | 59 | Illinois (227) | Final | W | 23 |
| 30 | 2022-02-24 | Purdue (72) | 51 | 68 | Northwestern (60) | Final | W | 17 |
| 31 | 2022-02-27 | Northwestern (60) | 59 | 73 | Nebraska (30) | Final | L | -14 |
| 32 | 2022-03-03 | Minnesota (99) | 60 | 65 | Northwestern (61) | Final | W | 5 |
| 33 | 2022-03-04 | Northwestern (61) | 59 | 72 | Iowa (19) | Final | L | -13 |