NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | IUPUI (72) | 62 | 67 | Michigan (24) | Final/OT | L | -5 |
| 2 | 2021-11-14 | IUPUI (72) | 71 | 60 | Bowling Green (63) | Final | W | 11 |
| 3 | 2021-11-20 | IUPUI (119) | 0 | 0 | Purdue Fort Wayne (131) | Forfeit | - | - |
| 4 | 2021-11-24 | IUPUI (125) | 0 | 0 | Southern Illinois (244) | Cancelled | - | - |
| 5 | 2021-11-28 | Butler (307) | 47 | 80 | IUPUI (125) | Final | W | 33 |
| 6 | 2021-12-02 | IUPUI (100) | 87 | 52 | Detroit (348) | Final | W | 35 |
| 7 | 2021-12-08 | Ball State (134) | 73 | 67 | IUPUI (85) | Final | L | -6 |
| 8 | 2021-12-21 | IUPUI (114) | 74 | 73 | Iowa (34) | Final | W | 1 |
| 9 | 2022-01-06 | Green Bay (148) | 49 | 51 | IUPUI (103) | Final | W | 2 |
| 10 | 2022-01-14 | IUPUI (89) | 63 | 44 | Robert Morris (273) | Final | W | 19 |
| 11 | 2022-01-21 | Illinois-Chicago (335) | 44 | 82 | IUPUI (73) | Final | W | 38 |
| 12 | 2022-01-29 | Cleveland State (162) | 64 | 82 | IUPUI (67) | Final | W | 18 |
| 13 | 2022-02-04 | Oakland (203) | 56 | 64 | IUPUI (61) | Final | W | 8 |
| 14 | 2022-02-06 | Detroit (355) | 49 | 66 | IUPUI (61) | Final | W | 17 |
| 15 | 2022-02-12 | IUPUI (62) | 78 | 53 | Northern Kentucky (120) | Final | W | 25 |
| 16 | 2022-02-17 | IUPUI (60) | 71 | 59 | Milwaukee (215) | Final | W | 12 |
| 17 | 2022-02-19 | IUPUI (60) | 56 | 71 | Green Bay (106) | Final | L | -15 |
| 18 | 2022-02-24 | Youngstown State (98) | 45 | 68 | IUPUI (70) | Final | W | 23 |
| 19 | 2022-02-26 | Robert Morris (251) | 40 | 73 | IUPUI (70) | Final | W | 33 |
| 20 | 2022-03-03 | Robert Morris (252) | 41 | 72 | IUPUI (66) | Final | W | 31 |
| 21 | 2022-03-07 | Oakland (226) | 63 | 86 | IUPUI (66) | Final | W | 23 |
| 22 | 2022-03-08 | Cleveland State (131) | 54 | 61 | IUPUI (61) | Final | W | 7 |
| 23 | 2022-03-19 | IUPUI (57) | 72 | 78 | Oklahoma (15) | Final | L | -6 |