NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Long Island (261) | 66 | 85 | Penn State (104) | Final | W | 19 |
| 2 | 2021-11-11 | Rider (339) | 69 | 83 | Penn State (96) | Final | W | 14 |
| 3 | 2021-11-16 | Delaware State (343) | 51 | 120 | Penn State (66) | Final | W | 69 |
| 4 | 2021-11-21 | Penn State (66) | 64 | 67 | Clemson (144) | Final | L | -3 |
| 5 | 2021-11-26 | St. John's (87) | 75 | 80 | Penn State (96) | Final | W | 5 |
| 6 | 2021-11-27 | Penn State (123) | 59 | 93 | Iowa State (36) | Final | L | -34 |
| 7 | 2021-11-28 | Penn State (123) | 74 | 81 | Kent State (75) | Final | L | -7 |
| 8 | 2021-12-02 | Penn State (122) | 69 | 86 | Boston College (64) | Final | L | -17 |
| 9 | 2021-12-06 | Penn State (122) | 40 | 70 | Indiana (43) | Final | L | -30 |
| 10 | 2021-12-09 | Rutgers (146) | 48 | 52 | Penn State (135) | Final | W | 4 |
| 11 | 2021-12-12 | Youngstown State (68) | 58 | 78 | Penn State (135) | Final | W | 20 |
| 12 | 2021-12-18 | Penn State (96) | 68 | 60 | Duquesne (238) | Final | W | 8 |
| 13 | 2021-12-22 | Towson (41) | 0 | 0 | Penn State (111) | Cancelled | - | - |
| 14 | 2021-12-30 | Iowa (51) | 0 | 0 | Penn State (110) | Cancelled | - | - |
| 15 | 2022-01-03 | Penn State (110) | 0 | 0 | Ohio State (30) | Postponed | - | - |
| 16 | 2022-01-06 | Penn State (119) | 78 | 106 | Maryland (25) | Final | L | -28 |
| 17 | 2022-01-13 | Michigan (6) | 74 | 57 | Penn State (96) | Final | L | -17 |
| 18 | 2022-01-16 | Illinois (29) | 72 | 90 | Penn State (96) | Final | W | 18 |
| 19 | 2022-01-20 | Penn State (114) | 63 | 59 | Northwestern (60) | Final | W | 4 |
| 20 | 2022-01-23 | Penn State (96) | 57 | 69 | Wisconsin (77) | Final | L | -12 |
| 21 | 2022-01-25 | Iowa (26) | 107 | 79 | Penn State (119) | Final | L | -28 |
| 22 | 2022-01-27 | Michigan State (19) | 79 | 58 | Penn State (96) | Final | L | -21 |
| 23 | 2022-01-30 | Maryland (22) | 82 | 71 | Penn State (119) | Final | L | -11 |
| 24 | 2022-02-03 | Penn State (129) | 61 | 76 | Nebraska (24) | Final | L | -15 |
| 25 | 2022-02-06 | Northwestern (77) | 78 | 72 | Penn State (129) | Final | L | -6 |
| 26 | 2022-02-09 | Penn State (96) | 77 | 81 | Purdue (84) | Final | L | -4 |
| 27 | 2022-02-13 | Penn State (131) | 62 | 71 | Rutgers (183) | Final | L | -9 |
| 28 | 2022-02-17 | Nebraska (25) | 76 | 83 | Penn State (149) | Final | W | 7 |
| 29 | 2022-02-21 | Penn State (149) | 79 | 71 | Michigan State (78) | Final | W | 8 |
| 30 | 2022-02-24 | Penn State (119) | 55 | 78 | Ohio State (28) | Final | L | -23 |
| 31 | 2022-02-27 | Minnesota (110) | 94 | 83 | Penn State (119) | Final | L | -11 |
| 32 | 2022-03-02 | Rutgers (160) | 75 | 50 | Penn State (123) | Final | L | -25 |