Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-27 | Bryant (349) | 84 | 85 | Syracuse (84) | Final | W | 1 |
| 2 | 2020-12-03 | Niagara (342) | 45 | 75 | Syracuse (84) | Final | W | 30 |
| 3 | 2020-12-05 | Rider (356) | 52 | 87 | Syracuse (84) | Final | W | 35 |
| 4 | 2020-12-08 | Syracuse (84) | 69 | 79 | Rutgers (112) | Final | L | -10 |
| 5 | 2020-12-12 | Syracuse (84) | 101 | 63 | Boston College (151) | Final | W | 38 |
| 6 | 2020-12-16 | Northeastern (300) | 56 | 62 | Syracuse (84) | Final | W | 6 |
| 7 | 2020-12-19 | Buffalo (219) | 96 | 107 | Syracuse (84) | Final/OT | W | 11 |
| 8 | 2020-12-22 | Notre Dame (101) | 0 | 0 | Syracuse (84) | Postponed | - | - |
| 9 | 2020-12-30 | Syracuse (84) | 0 | 0 | Wake Forest (70) | Cancelled | - | - |
| 10 | 2021-01-02 | Syracuse (31) | 0 | 0 | North Carolina (77) | Cancelled | - | - |
| 11 | 2021-01-06 | Florida State (48) | 0 | 0 | Syracuse (30) | Cancelled | - | - |
| 12 | 2021-01-06 | Pittsburgh (108) | 63 | 60 | Syracuse (84) | Final | L | -3 |
| 13 | 2021-01-09 | Georgetown (83) | 69 | 74 | Syracuse (84) | Final | W | 5 |
| 14 | 2021-01-12 | Clemson (9) | 0 | 0 | Syracuse (42) | Cancelled | - | - |
| 15 | 2021-01-12 | Syracuse (84) | 75 | 81 | North Carolina (22) | Final | L | -6 |
| 16 | 2021-01-16 | Syracuse (84) | 76 | 96 | Pittsburgh (108) | Final | L | -20 |
| 17 | 2021-01-19 | Miami (27) | 57 | 83 | Syracuse (84) | Final | W | 26 |
| 18 | 2021-01-23 | Virginia Tech (56) | 60 | 78 | Syracuse (84) | Final | W | 18 |
| 19 | 2021-01-25 | Syracuse (84) | 58 | 81 | Virginia (14) | Final | L | -23 |
| 20 | 2021-01-31 | North Carolina State (44) | 73 | 76 | Syracuse (84) | Final | W | 3 |
| 21 | 2021-02-03 | Louisville (21) | 0 | 0 | Syracuse (84) | Cancelled | - | - |
| 22 | 2021-02-06 | Syracuse (84) | 61 | 78 | Clemson (36) | Final | L | -17 |
| 23 | 2021-02-09 | Syracuse (84) | 77 | 68 | North Carolina State (44) | Final | W | 9 |
| 24 | 2021-02-13 | Boston College (151) | 67 | 75 | Syracuse (84) | Final | W | 8 |
| 25 | 2021-02-17 | Syracuse (84) | 0 | 0 | Louisville (21) | Cancelled | - | - |
| 26 | 2021-02-20 | Notre Dame (101) | 67 | 75 | Syracuse (84) | Final | W | 8 |
| 27 | 2021-02-22 | Syracuse (84) | 71 | 85 | Duke (3) | Final | L | -14 |
| 28 | 2021-02-27 | Syracuse (84) | 77 | 84 | Georgia Tech (158) | Final | L | -7 |
| 29 | 2021-03-01 | North Carolina (42) | 70 | 72 | Syracuse (63) | Final | W | 2 |
| 30 | 2021-03-03 | Clemson (36) | 54 | 64 | Syracuse (84) | Final | W | 10 |
| 31 | 2021-03-10 | North Carolina State (74) | 68 | 89 | Syracuse (51) | Final | W | 21 |
| 32 | 2021-03-11 | Syracuse (84) | 69 | 72 | Virginia (14) | Final | L | -3 |
| 33 | 2021-03-19 | Syracuse (45) | 78 | 62 | San Diego State (11) | Final | W | 16 |
| 34 | 2021-03-21 | Syracuse (45) | 75 | 72 | West Virginia (17) | Final | W | 3 |
| 35 | 2021-03-27 | Syracuse (45) | 46 | 62 | Houston (5) | Final | L | -16 |