Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-29 | North Florida (345) | 59 | 77 | Miami (27) | Final | W | 18 |
| 2 | 2020-12-04 | Stetson (301) | 60 | 82 | Miami (27) | Final | W | 22 |
| 3 | 2020-12-08 | Purdue (8) | 54 | 58 | Miami (27) | Final | W | 4 |
| 4 | 2020-12-12 | Florida Gulf Coast (241) | 66 | 62 | Miami (27) | Final | L | -4 |
| 5 | 2020-12-16 | Pittsburgh (108) | 70 | 55 | Miami (27) | Final | L | -15 |
| 6 | 2020-12-19 | Jacksonville (281) | 64 | 73 | Miami (27) | Final | W | 9 |
| 7 | 2020-12-29 | Miami (27) | 78 | 80 | Virginia Tech (56) | Final | L | -2 |
| 8 | 2021-01-02 | Clemson (36) | 66 | 65 | Miami (27) | Final | L | -1 |
| 9 | 2021-01-05 | North Carolina (22) | 67 | 65 | Miami (27) | Final | L | -2 |
| 10 | 2021-01-09 | Miami (27) | 64 | 59 | North Carolina State (44) | Final | W | 5 |
| 11 | 2021-01-12 | Miami (27) | 62 | 84 | Boston College (151) | Final | L | -22 |
| 12 | 2021-01-16 | Louisville (21) | 72 | 78 | Miami (27) | Final | W | 6 |
| 13 | 2021-01-19 | Miami (27) | 57 | 83 | Syracuse (84) | Final | L | -26 |
| 14 | 2021-01-24 | Notre Dame (101) | 73 | 59 | Miami (27) | Final | L | -14 |
| 15 | 2021-01-27 | Miami (27) | 59 | 81 | Florida State (64) | Final | L | -22 |
| 16 | 2021-01-30 | Miami (27) | 54 | 66 | Wake Forest (70) | Final | L | -12 |
| 17 | 2021-02-01 | Duke (3) | 75 | 77 | Miami (27) | Final | W | 2 |
| 18 | 2021-02-06 | Virginia Tech (56) | 80 | 76 | Miami (27) | Final/OT | L | -4 |
| 19 | 2021-02-08 | Miami (27) | 0 | 0 | North Carolina (22) | Cancelled | - | - |
| 20 | 2021-02-14 | Miami (27) | 61 | 71 | Notre Dame (101) | Final | L | -10 |
| 21 | 2021-02-20 | Georgia Tech (158) | 87 | 60 | Miami (27) | Final | L | -27 |
| 22 | 2021-02-24 | Florida State (64) | 88 | 71 | Miami (27) | Final | L | -17 |
| 23 | 2021-02-27 | Miami (27) | 58 | 66 | Clemson (36) | Final | L | -8 |
| 24 | 2021-03-01 | Miami (166) | 51 | 62 | Virginia (27) | Final | L | -11 |
| 25 | 2021-03-05 | Boston College (151) | 76 | 80 | Miami (27) | Final | W | 4 |
| 26 | 2021-03-09 | Miami (27) | 79 | 73 | Pittsburgh (108) | Final | W | 6 |
| 27 | 2021-03-10 | Miami (159) | 67 | 64 | Clemson (26) | Final | W | 3 |
| 28 | 2021-03-11 | Miami (27) | 66 | 70 | Georgia Tech (158) | Final | L | -4 |