Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-27 | Gardner-Webb (363) | 0 | 0 | Florida State (64) | Postponed | - | - |
| 2 | 2020-12-02 | North Florida (345) | 58 | 86 | Florida State (64) | Final | W | 28 |
| 3 | 2020-12-09 | Indiana (46) | 67 | 69 | Florida State (64) | Final/OT | W | 2 |
| 4 | 2020-12-12 | Florida (6) | 71 | 83 | Florida State (64) | Final | W | 12 |
| 5 | 2020-12-15 | Georgia Tech (158) | 61 | 74 | Florida State (64) | Final | W | 13 |
| 6 | 2020-12-19 | Central Florida (43) | 86 | 74 | Florida State (64) | Final | L | -12 |
| 7 | 2020-12-21 | Gardner-Webb (363) | 59 | 72 | Florida State (64) | Final | W | 13 |
| 8 | 2020-12-29 | Florida State (64) | 67 | 77 | Clemson (36) | Final | L | -10 |
| 9 | 2021-01-02 | Duke (3) | 0 | 0 | Florida State (64) | Cancelled | - | - |
| 10 | 2021-01-06 | Florida State (48) | 0 | 0 | Syracuse (30) | Cancelled | - | - |
| 11 | 2021-01-09 | Florida State (64) | 0 | 0 | Pittsburgh (108) | Postponed | - | - |
| 12 | 2021-01-13 | North Carolina State (44) | 73 | 105 | Florida State (64) | Final | W | 32 |
| 13 | 2021-01-16 | North Carolina (22) | 75 | 82 | Florida State (64) | Final | W | 7 |
| 14 | 2021-01-18 | Florida State (64) | 78 | 65 | Louisville (21) | Final | W | 13 |
| 15 | 2021-01-23 | Clemson (36) | 61 | 80 | Florida State (64) | Final | W | 19 |
| 16 | 2021-01-27 | Miami (27) | 59 | 81 | Florida State (64) | Final | W | 22 |
| 17 | 2021-01-30 | Florida State (64) | 65 | 76 | Georgia Tech (158) | Final | L | -11 |
| 18 | 2021-02-02 | Florida State (64) | 0 | 0 | Boston College (151) | Cancelled | - | - |
| 19 | 2021-02-06 | Florida State (19) | 0 | 0 | Pittsburgh (85) | Cancelled | - | - |
| 20 | 2021-02-09 | Florida State (64) | 0 | 0 | Virginia Tech (56) | Cancelled | - | - |
| 21 | 2021-02-13 | Wake Forest (70) | 85 | 92 | Florida State (64) | Final/OT | W | 7 |
| 22 | 2021-02-15 | Virginia (14) | 60 | 81 | Florida State (64) | Final | W | 21 |
| 23 | 2021-02-20 | Virginia Tech (28) | 0 | 0 | Florida State (17) | Cancelled | - | - |
| 24 | 2021-02-20 | Florida State (64) | 79 | 72 | Pittsburgh (108) | Final | W | 7 |
| 25 | 2021-02-24 | Florida State (64) | 88 | 71 | Miami (27) | Final | W | 17 |
| 26 | 2021-02-27 | Florida State (64) | 70 | 78 | North Carolina (22) | Final | L | -8 |
| 27 | 2021-03-03 | Boston College (151) | 64 | 93 | Florida State (64) | Final | W | 29 |
| 28 | 2021-03-06 | Florida State (64) | 73 | 83 | Notre Dame (101) | Final | L | -10 |
| 29 | 2021-03-11 | Duke (3) | 0 | 1 | Florida State (64) | Cancelled | W | 1 |
| 30 | 2021-03-11 | Duke (69) | 0 | 0 | Florida State (20) | Cancelled | - | - |
| 31 | 2021-03-12 | North Carolina (22) | 66 | 69 | Florida State (64) | Final | W | 3 |
| 32 | 2021-03-13 | Georgia Tech (42) | 80 | 75 | Florida State (20) | Final | L | -5 |
| 33 | 2021-03-20 | UNC-Greensboro (93) | 54 | 64 | Florida State (20) | Final | W | 10 |
| 34 | 2021-03-22 | Colorado (23) | 53 | 71 | Florida State (20) | Final | W | 18 |
| 35 | 2021-03-28 | Florida State (20) | 58 | 76 | Michigan (4) | Final | L | -18 |