Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Gannon | 0 | 0 | Buffalo (219) | Cancelled | - | - |
| 2 | 2020-11-25 | Gannon | Buffalo (125) | Cancelled | - | - | ||
| 3 | 2020-11-27 | Buffalo (219) | 74 | 65 | Towson (152) | Final | W | 9 |
| 4 | 2020-11-28 | Buffalo (219) | 74 | 78 | Army (339) | Final | L | -4 |
| 5 | 2020-12-01 | Iona (173) | Buffalo (238) | Cancelled | - | - | ||
| 6 | 2020-12-06 | Buffalo (219) | 78 | 86 | Bowling Green (168) | Final | L | -8 |
| 7 | 2020-12-10 | Mercyhurst (284) | 64 | 81 | Buffalo (219) | Final | W | 17 |
| 8 | 2020-12-15 | Buffalo (219) | 90 | 62 | Miami (OH) (40) | Final | W | 28 |
| 9 | 2020-12-19 | Buffalo (219) | 96 | 107 | Syracuse (84) | Final/OT | L | -11 |
| 10 | 2020-12-22 | Buffalo (219) | 0 | 0 | St. Bonaventure (146) | Cancelled | - | - |
| 11 | 2020-12-22 | Buffalo (186) | St. Bonaventure (76) | Cancelled | - | - | ||
| 12 | 2020-12-29 | Buffalo (196) | West Virginia (19) | Cancelled | - | - | ||
| 13 | 2021-01-01 | Buffalo (196) | 0 | 0 | Akron (119) | Cancelled | - | - |
| 14 | 2021-01-05 | Eastern Michigan (286) | 0 | 0 | Buffalo (185) | Cancelled | - | - |
| 15 | 2021-01-09 | Ball State (298) | 69 | 86 | Buffalo (219) | Final | W | 17 |
| 16 | 2021-01-12 | Buffalo (219) | 85 | 69 | Western Michigan (304) | Final | W | 16 |
| 17 | 2021-01-15 | Bowling Green (168) | 76 | 69 | Buffalo (219) | Final | L | -7 |
| 18 | 2021-01-19 | Buffalo (219) | 81 | 84 | Kent State (107) | Final | L | -3 |
| 19 | 2021-01-21 | Eastern Michigan (277) | 77 | 92 | Buffalo (219) | Final | W | 15 |
| 20 | 2021-01-23 | Buffalo (219) | 0 | 0 | Northern Illinois (326) | Postponed | - | - |
| 21 | 2021-01-26 | Central Michigan (311) | 0 | 0 | Buffalo (219) | Postponed | - | - |
| 22 | 2021-01-29 | Ohio (218) | 76 | 75 | Buffalo (219) | Final | L | -1 |
| 23 | 2021-02-02 | Buffalo (219) | 78 | 58 | Ball State (298) | Final | W | 20 |
| 24 | 2021-02-06 | Miami (OH) (40) | 64 | 88 | Buffalo (219) | Final | W | 24 |
| 25 | 2021-02-09 | Western Michigan (304) | 0 | 0 | Buffalo (219) | Postponed | - | - |
| 26 | 2021-02-12 | Buffalo (146) | 0 | 0 | Central Michigan (285) | Cancelled | - | - |
| 27 | 2021-02-12 | Western Michigan (304) | 54 | 86 | Buffalo (219) | Final | W | 32 |
| 28 | 2021-02-16 | Buffalo (219) | 0 | 0 | Eastern Michigan (277) | Cancelled | - | - |
| 29 | 2021-02-19 | Toledo (135) | 80 | 70 | Buffalo (219) | Final | L | -10 |
| 30 | 2021-02-23 | Buffalo (219) | 102 | 74 | Northern Illinois (326) | Final | W | 28 |
| 31 | 2021-02-25 | Central Michigan (311) | 73 | 85 | Buffalo (219) | Final | W | 12 |
| 32 | 2021-02-27 | Buffalo (219) | 86 | 66 | Ohio (218) | Final | W | 20 |
| 33 | 2021-03-02 | Akron (59) | 78 | 80 | Buffalo (219) | Final | W | 2 |
| 34 | 2021-03-05 | Kent State (107) | 67 | 81 | Buffalo (219) | Final | W | 14 |
| 35 | 2021-03-11 | Miami (OH) (40) | 63 | 74 | Buffalo (219) | Final | W | 11 |
| 36 | 2021-03-12 | Akron (59) | 74 | 81 | Buffalo (219) | Final/OT | W | 7 |
| 37 | 2021-03-13 | Ohio (118) | 84 | 69 | Buffalo (104) | Final | L | -15 |
| 38 | 2021-03-19 | Buffalo (99) | 73 | 75 | Colorado State (52) | Final | L | -2 |