Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Mississippi State (100) | 42 | 53 | Clemson (36) | Final | W | 11 |
| 2 | 2020-11-25 | Clemson (74) | 53 | 42 | Mississippi State (53) | Final | W | 11 |
| 3 | 2020-11-26 | Purdue (8) | 70 | 81 | Clemson (36) | Final | W | 11 |
| 4 | 2020-12-02 | South Carolina State (355) | 38 | 75 | Clemson (36) | Final | W | 37 |
| 5 | 2020-12-09 | Maryland (114) | 51 | 67 | Clemson (36) | Final | W | 16 |
| 6 | 2020-12-12 | Clemson (36) | 64 | 56 | Alabama (15) | Final | W | 8 |
| 7 | 2020-12-12 | Alabama (65) | 56 | 64 | Clemson (15) | Final | W | 8 |
| 8 | 2020-12-15 | Clemson (36) | 60 | 66 | Virginia Tech (56) | Final | L | -6 |
| 9 | 2020-12-19 | Clemson (36) | 0 | 0 | South Carolina (110) | Cancelled | - | - |
| 10 | 2020-12-21 | Morehead State (233) | 51 | 66 | Clemson (36) | Final | W | 15 |
| 11 | 2020-12-29 | Florida State (64) | 67 | 77 | Clemson (36) | Final | W | 10 |
| 12 | 2021-01-02 | Clemson (36) | 66 | 65 | Miami (27) | Final | W | 1 |
| 13 | 2021-01-05 | North Carolina State (44) | 70 | 74 | Clemson (36) | Final/OT | W | 4 |
| 14 | 2021-01-09 | Clemson (36) | 0 | 0 | North Carolina (22) | Cancelled | - | - |
| 15 | 2021-01-12 | Clemson (9) | 0 | 0 | Syracuse (42) | Cancelled | - | - |
| 16 | 2021-01-16 | Virginia (14) | 85 | 50 | Clemson (36) | Final | L | -35 |
| 17 | 2021-01-20 | Clemson (36) | 65 | 83 | Georgia Tech (158) | Final | L | -18 |
| 18 | 2021-01-23 | Clemson (36) | 61 | 80 | Florida State (64) | Final | L | -19 |
| 19 | 2021-01-27 | Louisville (21) | 50 | 54 | Clemson (36) | Final | W | 4 |
| 20 | 2021-01-27 | Boston College (151) | 0 | 0 | Clemson (36) | Postponed | - | - |
| 21 | 2021-01-30 | Clemson (36) | 53 | 79 | Duke (3) | Final | L | -26 |
| 22 | 2021-02-02 | North Carolina (22) | 50 | 63 | Clemson (36) | Final | W | 13 |
| 23 | 2021-02-06 | Syracuse (84) | 61 | 78 | Clemson (36) | Final | W | 17 |
| 24 | 2021-02-12 | Georgia Tech (158) | 72 | 74 | Clemson (36) | Final | W | 2 |
| 25 | 2021-02-17 | Clemson (36) | 0 | 0 | Notre Dame (101) | Cancelled | - | - |
| 26 | 2021-02-21 | Clemson (36) | 0 | 0 | Pittsburgh (108) | Cancelled | - | - |
| 27 | 2021-02-24 | Clemson (36) | 60 | 39 | Wake Forest (70) | Final | W | 21 |
| 28 | 2021-02-27 | Miami (27) | 58 | 66 | Clemson (36) | Final | W | 8 |
| 29 | 2021-03-03 | Clemson (36) | 54 | 64 | Syracuse (84) | Final | L | -10 |
| 30 | 2021-03-06 | Pittsburgh (108) | 62 | 77 | Clemson (36) | Final | W | 15 |
| 31 | 2021-03-10 | Miami (159) | 67 | 64 | Clemson (26) | Final | L | -3 |
| 32 | 2021-03-19 | Rutgers (35) | 60 | 56 | Clemson (31) | Final | L | -4 |