Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | St. Francis (PA) (159) | 80 | 70 | Pittsburgh (99) | Final | L | -10 |
| 2 | 2020-11-28 | Drexel (215) | 74 | 83 | Pittsburgh (108) | Final | W | 9 |
| 3 | 2020-12-05 | Northern Illinois (326) | 59 | 89 | Pittsburgh (108) | Final | W | 30 |
| 4 | 2020-12-09 | Pittsburgh (108) | 71 | 70 | Northwestern (75) | Final | W | 1 |
| 5 | 2020-12-12 | Gardner-Webb (363) | 50 | 67 | Pittsburgh (108) | Final | W | 17 |
| 6 | 2020-12-16 | Pittsburgh (108) | 70 | 55 | Miami (27) | Final | W | 15 |
| 7 | 2020-12-22 | Louisville (21) | 64 | 54 | Pittsburgh (108) | Final | L | -10 |
| 8 | 2020-12-29 | Pittsburgh (108) | 0 | 0 | Duke (3) | Cancelled | - | - |
| 9 | 2021-01-02 | Notre Dame (198) | 0 | 0 | Pittsburgh (70) | Cancelled | - | - |
| 10 | 2021-01-06 | Pittsburgh (108) | 63 | 60 | Syracuse (84) | Final | W | 3 |
| 11 | 2021-01-09 | Florida State (64) | 0 | 0 | Pittsburgh (108) | Postponed | - | - |
| 12 | 2021-01-13 | Pittsburgh (108) | 0 | 0 | Georgia Tech (158) | Postponed | - | - |
| 13 | 2021-01-16 | Syracuse (84) | 76 | 96 | Pittsburgh (108) | Final | W | 20 |
| 14 | 2021-01-19 | Duke (3) | 73 | 79 | Pittsburgh (108) | Final | W | 6 |
| 15 | 2021-01-23 | Pittsburgh (108) | 0 | 0 | Boston College (151) | Cancelled | - | - |
| 16 | 2021-01-23 | Pittsburgh (108) | 75 | 76 | Wake Forest (70) | Final | L | -1 |
| 17 | 2021-01-26 | North Carolina (22) | 75 | 65 | Pittsburgh (108) | Final | L | -10 |
| 18 | 2021-01-30 | Notre Dame (125) | 84 | 58 | Pittsburgh (60) | Final | L | -26 |
| 19 | 2021-01-31 | Notre Dame (101) | 84 | 58 | Pittsburgh (108) | Final | L | -26 |
| 20 | 2021-02-03 | Virginia Tech (56) | 72 | 83 | Pittsburgh (108) | Final | W | 11 |
| 21 | 2021-02-06 | Florida State (19) | 0 | 0 | Pittsburgh (85) | Cancelled | - | - |
| 22 | 2021-02-06 | Pittsburgh (108) | 66 | 73 | Virginia (14) | Final | L | -7 |
| 23 | 2021-02-10 | Pittsburgh (108) | 0 | 0 | Louisville (21) | Cancelled | - | - |
| 24 | 2021-02-14 | Pittsburgh (108) | 65 | 71 | Georgia Tech (158) | Final | L | -6 |
| 25 | 2021-02-17 | North Carolina State (44) | 74 | 73 | Pittsburgh (108) | Final | L | -1 |
| 26 | 2021-02-20 | Florida State (64) | 79 | 72 | Pittsburgh (108) | Final | L | -7 |
| 27 | 2021-02-21 | Clemson (36) | 0 | 0 | Pittsburgh (108) | Cancelled | - | - |
| 28 | 2021-02-28 | Pittsburgh (108) | 62 | 65 | North Carolina State (44) | Final | L | -3 |
| 29 | 2021-03-02 | Wake Forest (70) | 57 | 70 | Pittsburgh (108) | Final | W | 13 |
| 30 | 2021-03-06 | Pittsburgh (108) | 62 | 77 | Clemson (36) | Final | L | -15 |
| 31 | 2021-03-09 | Miami (27) | 79 | 73 | Pittsburgh (108) | Final | L | -6 |